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Molecules 2012, 17(1), 989-1001; doi:10.3390/molecules17010989
Article

Synthesis, Structure and Antifungal Activity of New 3-[(5-Aryl-1,3,4-oxadiazol-2-yl)methyl]benzo[d]thiazol-2(3H)-ones

1,* , 1
,
1
,
1
 and
2
1 College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, China 2 Department of Bioassay, Zhejiang Branch of National Southern Pesticide Research Centre, Hangzhou 310023, China
* Author to whom correspondence should be addressed.
Received: 7 December 2011 / Revised: 6 January 2012 / Accepted: 9 January 2012 / Published: 18 January 2012
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Abstract

A series of new 3-[(5-aryl-1,3,4-oxadiazol-2-yl)methy])benzo[d]thiazol-2(3H)-ones were synthesized by reaction of (5-substituted-2-oxobenzothiazolin-3-yl)-acetohydrazide with various aromatic acids in POCl3 under reflux conditions. The structures of the title compounds were confirmed by 1H-NMR, 13C-NMR, IR, MS and elemental analysis. Furthermore, the structure of compound 4i was determined by single-crystal X-ray diffraction. The preliminary bioassy results indicated that some of them showed moderate inhibition activity against Colletotrichum orbiculare, Botrytis cinerea and Rhizoctonia solani.
Keywords: 3-[(5-aryl-1,3,4-oxadiazol-2-yl)methyl]benzo[d]thiazol-2(3H)-ones; synthesis; crystal structure; antifungal activity 3-[(5-aryl-1,3,4-oxadiazol-2-yl)methyl]benzo[d]thiazol-2(3H)-ones; synthesis; crystal structure; antifungal activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Weng, J.-Q.; Liu, X.-H.; Huang, H.; Tan, C.-X.; Chen, J. Synthesis, Structure and Antifungal Activity of New 3-[(5-Aryl-1,3,4-oxadiazol-2-yl)methyl]benzo[d]thiazol-2(3H)-ones. Molecules 2012, 17, 989-1001.

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