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Molecules 2012, 17(1), 989-1001; doi:10.3390/molecules17010989
Article

Synthesis, Structure and Antifungal Activity of New 3-[(5-Aryl-1,3,4-oxadiazol-2-yl)methyl]benzo[d]thiazol-2(3H)-ones

1,* , 1
,
1
,
1
 and
2
1 College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, China 2 Department of Bioassay, Zhejiang Branch of National Southern Pesticide Research Centre, Hangzhou 310023, China
* Author to whom correspondence should be addressed.
Received: 7 December 2011 / Revised: 6 January 2012 / Accepted: 9 January 2012 / Published: 18 January 2012
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Abstract

A series of new 3-[(5-aryl-1,3,4-oxadiazol-2-yl)methy])benzo[d]thiazol-2(3H)-ones were synthesized by reaction of (5-substituted-2-oxobenzothiazolin-3-yl)-acetohydrazide with various aromatic acids in POCl3 under reflux conditions. The structures of the title compounds were confirmed by 1H-NMR, 13C-NMR, IR, MS and elemental analysis. Furthermore, the structure of compound 4i was determined by single-crystal X-ray diffraction. The preliminary bioassy results indicated that some of them showed moderate inhibition activity against Colletotrichum orbiculare, Botrytis cinerea and Rhizoctonia solani.
Keywords: 3-[(5-aryl-1,3,4-oxadiazol-2-yl)methyl]benzo[d]thiazol-2(3H)-ones; synthesis; crystal structure; antifungal activity 3-[(5-aryl-1,3,4-oxadiazol-2-yl)methyl]benzo[d]thiazol-2(3H)-ones; synthesis; crystal structure; antifungal activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Weng, J.-Q.; Liu, X.-H.; Huang, H.; Tan, C.-X.; Chen, J. Synthesis, Structure and Antifungal Activity of New 3-[(5-Aryl-1,3,4-oxadiazol-2-yl)methyl]benzo[d]thiazol-2(3H)-ones. Molecules 2012, 17, 989-1001.

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