Synthesis, Structure and Antifungal Activity of New 3-[(5-Aryl-1,3,4-oxadiazol-2-yl)methyl]benzo[d]thiazol-2(3H)-ones

doi:10.3390/molecules17010989

This article is

freely available
re-usable

Molecules 2012, 17(1), 989-1001; doi:10.3390/molecules17010989

Article

Synthesis, Structure and Antifungal Activity of New 3-[(5-Aryl-1,3,4-oxadiazol-2-yl)methyl]benzo[d]thiazol-2(3H)-ones

Jian-Quan Weng^1,* , Xing-Hai Liu¹, Hua Huang¹, Cheng-Xia Tan¹ and Jie Chen²

¹ College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, China ² Department of Bioassay, Zhejiang Branch of National Southern Pesticide Research Centre, Hangzhou 310023, China

* Author to whom correspondence should be addressed.

Received: 7 December 2011; in revised form: 6 January 2012 / Accepted: 9 January 2012 / Published: 18 January 2012

Download PDF Full-Text [546 KB, uploaded 18 January 2012 12:04 CET]

Abstract: A series of new 3-[(5-aryl-1,3,4-oxadiazol-2-yl)methy])benzo[d]thiazol-2(3H)-ones were synthesized by reaction of (5-substituted-2-oxobenzothiazolin-3-yl)-acetohydrazide with various aromatic acids in POCl₃ under reflux conditions. The structures of the title compounds were confirmed by ¹H-NMR, ¹³C-NMR, IR, MS and elemental analysis. Furthermore, the structure of compound 4i was determined by single-crystal X-ray diffraction. The preliminary bioassy results indicated that some of them showed moderate inhibition activity against Colletotrichum orbiculare, Botrytis cinerea and Rhizoctonia solani.

Keywords: 3-[(5-aryl-1,3,4-oxadiazol-2-yl)methyl]benzo[d]thiazol-2(3H)-ones; synthesis; crystal structure; antifungal activity

Supplementary Files

Supplementary File 1:
DOC-Document (DOC, 3431 KB)

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Weng, J.-Q.; Liu, X.-H.; Huang, H.; Tan, C.-X.; Chen, J. Synthesis, Structure and Antifungal Activity of New 3-[(5-Aryl-1,3,4-oxadiazol-2-yl)methyl]benzo[d]thiazol-2(3H)-ones. Molecules 2012, 17, 989-1001.

AMA Style

Weng J-Q, Liu X-H, Huang H, Tan C-X, Chen J. Synthesis, Structure and Antifungal Activity of New 3-[(5-Aryl-1,3,4-oxadiazol-2-yl)methyl]benzo[d]thiazol-2(3H)-ones. Molecules. 2012; 17(1):989-1001.

Chicago/Turabian Style

Weng, Jian-Quan; Liu, Xing-Hai; Huang, Hua; Tan, Cheng-Xia; Chen, Jie. 2012. "Synthesis, Structure and Antifungal Activity of New 3-[(5-Aryl-1,3,4-oxadiazol-2-yl)methyl]benzo[d]thiazol-2(3H)-ones." Molecules 17, no. 1: 989-1001.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert