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Synthesis, Reactions and Antimicrobial Activities of 8-Ethoxycoumarin Derivatives
AbstractCondensation of 3-acetyl-8-ethoxycoumarin (3) with thiosemicarbazide gave ethylidenehydrazinecarbothioamide 5, which was transformed into the thiazolidin-4-one derivatives 6,7. Interaction of 3 with DMF/POCl3 gave b-chloroacroline derivative 8. Treatment of 3 with malononitrile gave benzo[c]chromone and 2-aminobenzonitrile derivatives 9 and 10, respectively with respect to the reaction conditions. Condensation of 3-(2-bromoacetyl)-8-ethoxycoumarin (4) with o-phenylenediamine gave 3-(quioxaline-2-yl)-8-ethoxycoumarin hydrobromide (11), while 4 reacted with 2-aminopyridine to give chromenopyridopyrimidine derivative 12. Condensation of 4 with potassium thio-cyanate/methanol gave an unexpected derivative, 2H-chromeno-3-carboxy(methyl-carbonimidic)thioanhydride 16, which upon treatment with (NH2)2·H2O gave 3-ethoxy-2-hydroxybenzaldehyde azine 19. Interaction of 4 with thiourea derivatives gave thiazole derivatives 20a–c. The structures of the newly synthesized compounds were confirmed by their spectra data. The newly synthesized compounds were also screened for their antimicrobial activity.
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Mohamed, H.M.; El-Wahab, A.H.F.A.; Ahmed, K.A.; El-Agrody, A.M.; Bedair, A.H.; Eid, F.A.; Khafagy, M.M. Synthesis, Reactions and Antimicrobial Activities of 8-Ethoxycoumarin Derivatives. Molecules 2012, 17, 971-988.View more citation formats
Mohamed HM, El-Wahab AHFA, Ahmed KA, El-Agrody AM, Bedair AH, Eid FA, Khafagy MM. Synthesis, Reactions and Antimicrobial Activities of 8-Ethoxycoumarin Derivatives. Molecules. 2012; 17(1):971-988.Chicago/Turabian Style
Mohamed, Hany M.; El-Wahab, Ashraf H. F. Abd; Ahmed, Kamal A.; El-Agrody, Ahmed M.; Bedair, Ahmed H.; Eid, Fathy A.; Khafagy, Mostafa M. 2012. "Synthesis, Reactions and Antimicrobial Activities of 8-Ethoxycoumarin Derivatives." Molecules 17, no. 1: 971-988.