Molecules 2012, 17(1), 934-950; doi:10.3390/molecules17010934
Article

Antioxidant Effect of Stryphnodendron rotundifolium Martius Extracts from Cariri-Ceará State (Brazil): Potential Involvement in Its Therapeutic Use

1 Department of Biological Chemistry, Laboratory of Natural Products, Program of Post-Graduation in Molecular Bioprospection, Regional University of Cariri, Street Cel. Antônio Luiz 1161, Pimenta, 63105-000 Crato-CE, Brazil 2 National Centre of Applied Electromagnetism, University of Oriente, Avenida de Las Américas, s/n. CP 90900, Santiago de Cuba, Cuba 3 Program of Post-Graduation in Biological Sciences-Biochemical Toxicology, Federal University of Santa Maria, Campus Camobi, Santa Maria, RS, 97105-900, Brazil 4 Program of Post-Graduation Pharmaceutical Science, Federal University of Santa Maria, Campus Camobi, Santa Maria, RS, 97105-900, Brazil 5 Vice-Rectory of Research and Post-Graduation, University of Fortaleza, Av. Washington Soares1321, Edson Queiroz, 60811-905, Fortaleza, CE, Brazil
* Author to whom correspondence should be addressed.
Received: 4 November 2011; in revised form: 16 December 2011 / Accepted: 20 December 2011 / Published: 18 January 2012
(This article belongs to the Section Natural Products)
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Abstract: Stryphnodendron rotundifolium is a phytotherapic used in the northeast of Brazil for the treatment of inflammatory processes which normally are associated with oxidative stress. Consequently, we have tested the antioxidant properties of hydroalcoholic (HAB) and aqueous extracts (AB) from the bark and aqueous extract (AL) from the leaves of Stryphnodendron rotundifolium to determine a possible association between antioxidant activity and the popular use of this plant. Free radical scavenger properties were assessed by the quenching of 1′,1′-diphenil-2-picrylhydrazyl (DPPH) and the calculated IC50 were: HAB = 5.4 ± 0.7, AB = 12.0 ± 2.6, and AL = 46.3 ± 12.3 µg/mL. Total phenolic contents were: HAB = 102.7 ± 2.8, AB = 114.4 ± 14.6, and AL = 93.8 ± 9.1 µg/mg plant). HPLC/DAD analyses indicated that gallic acid, catechin, rutin and caffeic acid were the major components of the crude extracts of S. rotundifolium. Plant extracts inhibited Fe(II)-induced lipid peroxidation in brain homogenates. Iron chelation was also investigated and only HBA exhibited a weak activity. Taken together, the results suggest that S. rotundifolium could be considered an effective agent in the prevention of diseases associated with oxidative stress.
Keywords: Stryphnodendron rotundifolium; antioxidant effects; oxidative stress; phenolic compounds; HPLC/DAD

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MDPI and ACS Style

Costa, J.G.M.; Leite, G.O.; Dubois, A.F.; Seeger, R.L.; Boligon, A.A.; Athayde, M.L.; Campos, A.R.; Rocha, J.B.T. Antioxidant Effect of Stryphnodendron rotundifolium Martius Extracts from Cariri-Ceará State (Brazil): Potential Involvement in Its Therapeutic Use. Molecules 2012, 17, 934-950.

AMA Style

Costa JGM, Leite GO, Dubois AF, Seeger RL, Boligon AA, Athayde ML, Campos AR, Rocha JBT. Antioxidant Effect of Stryphnodendron rotundifolium Martius Extracts from Cariri-Ceará State (Brazil): Potential Involvement in Its Therapeutic Use. Molecules. 2012; 17(1):934-950.

Chicago/Turabian Style

Costa, José Galberto Martins da; Leite, Gerlânia de Oliveira; Dubois, Albys Ferrer; Seeger, Rodrigo Lopes; Boligon, Aline Augusti; Athayde, Margareth Linde; Campos, Adriana Rolim; Rocha, João Batista Teixeira da. 2012. "Antioxidant Effect of Stryphnodendron rotundifolium Martius Extracts from Cariri-Ceará State (Brazil): Potential Involvement in Its Therapeutic Use." Molecules 17, no. 1: 934-950.

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