Two Novel Naphthalene Glucosides and an Anthraquinone Isolated from Rumex dentatus and Their Antiproliferation Activities in Four Cell Lines

doi:10.3390/molecules17010843

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Molecules 2012, 17(1), 843-850; doi:10.3390/molecules17010843

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Two Novel Naphthalene Glucosides and an Anthraquinone Isolated from Rumex dentatus and Their Antiproliferation Activities in Four Cell Lines

Hui Zhang, Zengjun Guo* , Nan Wu, Wenming Xu, Ling Han, Nan Li and Yanxia Han

Faculty of Pharmacy, School of Medicine, Xi'an Jiaotong University, No. 76 West Yanta Road, Xi'an 710061, China

* Author to whom correspondence should be addressed.

Received: 6 December 2011; in revised form: 6 January 2012 / Accepted: 9 January 2012 / Published: 17 January 2012

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Abstract: An ethyl acetate extract of the roots of Rumex dentatus L. was investigated. Three compounds were identified by their spectroscopic data as chrysophanol (1), 6-methyl-7-acetyl-1, 8-dihydroxy-3-methoxy naphthalene-1-O-β-D(L)-glucoside (2) and 6-methyl-7-acetyl-1, 8-dihydroxy naphthalene-1-O-β-D(L)-glucoside (3) were found in the plant for the first time. Compounds 2 and 3 are novel compounds. Their antiproliferation activities were tested by the MTT assay in four cell lines (breast cancer MCF-7, gastric cancer 7901, melanoma A375 and oophoroma SKOV-3).

Keywords: naphthalene; glucoside; anthraquinone; Rumex dentatus; antiproliferation

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Cite This Article

MDPI and ACS Style

Zhang, H.; Guo, Z.; Wu, N.; Xu, W.; Han, L.; Li, N.; Han, Y. Two Novel Naphthalene Glucosides and an Anthraquinone Isolated from Rumex dentatus and Their Antiproliferation Activities in Four Cell Lines. Molecules 2012, 17, 843-850.

AMA Style

Zhang H, Guo Z, Wu N, Xu W, Han L, Li N, Han Y. Two Novel Naphthalene Glucosides and an Anthraquinone Isolated from Rumex dentatus and Their Antiproliferation Activities in Four Cell Lines. Molecules. 2012; 17(1):843-850.

Chicago/Turabian Style

Zhang, Hui; Guo, Zengjun; Wu, Nan; Xu, Wenming; Han, Ling; Li, Nan; Han, Yanxia. 2012. "Two Novel Naphthalene Glucosides and an Anthraquinone Isolated from Rumex dentatus and Their Antiproliferation Activities in Four Cell Lines." Molecules 17, no. 1: 843-850.

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