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Molecules 2012, 17(1), 843-850; doi:10.3390/molecules17010843
Article

Two Novel Naphthalene Glucosides and an Anthraquinone Isolated from Rumex dentatus and Their Antiproliferation Activities in Four Cell Lines

, * , , , ,  and
Faculty of Pharmacy, School of Medicine, Xi'an Jiaotong University, No. 76 West Yanta Road, Xi'an 710061, China
* Author to whom correspondence should be addressed.
Received: 6 December 2011 / Revised: 6 January 2012 / Accepted: 9 January 2012 / Published: 17 January 2012
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Abstract

An ethyl acetate extract of the roots of Rumex dentatus L. was investigated. Three compounds were identified by their spectroscopic data as chrysophanol (1), 6-methyl-7-acetyl-1, 8-dihydroxy-3-methoxy naphthalene-1-O-β-D(L)-glucoside (2) and 6-methyl-7-acetyl-1, 8-dihydroxy naphthalene-1-O-β-D(L)-glucoside (3) were found in the plant for the first time. Compounds 2 and 3 are novel compounds. Their antiproliferation activities were tested by the MTT assay in four cell lines (breast cancer MCF-7, gastric cancer 7901, melanoma A375 and oophoroma SKOV-3).
Keywords: naphthalene; glucoside; anthraquinone; Rumex dentatus; antiproliferation naphthalene; glucoside; anthraquinone; Rumex dentatus; antiproliferation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhang, H.; Guo, Z.; Wu, N.; Xu, W.; Han, L.; Li, N.; Han, Y. Two Novel Naphthalene Glucosides and an Anthraquinone Isolated from Rumex dentatus and Their Antiproliferation Activities in Four Cell Lines. Molecules 2012, 17, 843-850.

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