Isostreptazolin and Sannaphenol, Two New Metabolites from Streptomyces sannanensis

doi:10.3390/molecules17010836

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Molecules 2012, 17(1), 836-842; doi:10.3390/molecules17010836

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Isostreptazolin and Sannaphenol, Two New Metabolites from Streptomyces sannanensis

Dan Zheng^1,†, Li Han^1,†, Yiqing Li^2,* , Jun Li², He Rong², Qiao Leng¹, Yi Jiang², Lixing Zhao² and Xueshi Huang^1,*

¹ Ministry of Health Key Laboratory of Congenital Malformation, Laboratory of Metabolic Disease Research and Drug Development, China Medical University, Shenyang 110001, China ² Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education, Yunnan University, Kunming 650091, China ^† These authors contributed equally to this work.

* Authors to whom correspondence should be addressed.

Received: 3 November 2011; in revised form: 12 January 2012 / Accepted: 13 January 2012 / Published: 16 January 2012

(This article belongs to the Section Natural Products)

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Abstract: Two new compounds, isostreptazolin (1) and sannaphenol (2), were isolated from the culture broth of Streptomyces sannanensis and their structures elucidated on the basis of 1D and 2D NMR as well as MS, IR and UV spectroscopic data analysis. The cytotoxic activity of 1 and 2 were evaluated. Both compounds were inactive against H460 and HeLa cell lines at 100 mM.

Keywords: isostreptazolin; sannaphenol; Streptomyces sannanensis

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Cite This Article

MDPI and ACS Style

Zheng, D.; Han, L.; Li, Y.; Li, J.; Rong, H.; Leng, Q.; Jiang, Y.; Zhao, L.; Huang, X. Isostreptazolin and Sannaphenol, Two New Metabolites from Streptomyces sannanensis. Molecules 2012, 17, 836-842.

AMA Style

Zheng D, Han L, Li Y, Li J, Rong H, Leng Q, Jiang Y, Zhao L, Huang X. Isostreptazolin and Sannaphenol, Two New Metabolites from Streptomyces sannanensis. Molecules. 2012; 17(1):836-842.

Chicago/Turabian Style

Zheng, Dan; Han, Li; Li, Yiqing; Li, Jun; Rong, He; Leng, Qiao; Jiang, Yi; Zhao, Lixing; Huang, Xueshi. 2012. "Isostreptazolin and Sannaphenol, Two New Metabolites from Streptomyces sannanensis." Molecules 17, no. 1: 836-842.

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