Next Article in Journal
Template Directed Reversible Photochemical Ligation of Oligodeoxynucleotides
Previous Article in Journal
The Biological Response of Spermidine Induced by Ionization Radiation
Molecules 2012, 17(1), 151-162; doi:10.3390/molecules17010151
Article

Synthesis of cis- and trans-3-Aminocyclohexanols by Reduction of β-Enaminoketones

, , ,  and *
Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Cuernavaca, Mor., CP 62209, Mexico
* Author to whom correspondence should be addressed.
Received: 25 October 2011 / Revised: 21 December 2011 / Accepted: 22 December 2011 / Published: 27 December 2011
(This article belongs to the Section Organic Synthesis)
Download PDF [337 KB, uploaded 18 June 2014]

Abstract

We describe a protocol developed for the preparation of β-enaminoketones derived from 1,3-cyclohexanediones, and their subsequent reduction by sodium in THF-isopropyl alcohol to afford cis- and trans-3-aminocyclohexanols.
Keywords: 1,3-amino alcohols; 3-aminocyclohexanols; β-enaminoketones; reduction of β-enaminoketones 1,3-amino alcohols; 3-aminocyclohexanols; β-enaminoketones; reduction of β-enaminoketones
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Balbás, I.M.; Mendoza, B.E.D.; Fernández-Zertuche, M.; Ordoñez, M.; Linzaga-Elizalde, I. Synthesis of cis- and trans-3-Aminocyclohexanols by Reduction of β-Enaminoketones. Molecules 2012, 17, 151-162.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert