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Molecules 2012, 17(1), 151-162; doi:10.3390/molecules17010151
Article

Synthesis of cis- and trans-3-Aminocyclohexanols by Reduction of β-Enaminoketones

, , ,  and *
Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Cuernavaca, Mor., CP 62209, Mexico
* Author to whom correspondence should be addressed.
Received: 25 October 2011 / Revised: 21 December 2011 / Accepted: 22 December 2011 / Published: 27 December 2011
(This article belongs to the Section Organic Synthesis)
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Abstract

We describe a protocol developed for the preparation of β-enaminoketones derived from 1,3-cyclohexanediones, and their subsequent reduction by sodium in THF-isopropyl alcohol to afford cis- and trans-3-aminocyclohexanols.
Keywords: 1,3-amino alcohols; 3-aminocyclohexanols; β-enaminoketones; reduction of β-enaminoketones 1,3-amino alcohols; 3-aminocyclohexanols; β-enaminoketones; reduction of β-enaminoketones
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Balbás, I.M.; Mendoza, B.E.D.; Fernández-Zertuche, M.; Ordoñez, M.; Linzaga-Elizalde, I. Synthesis of cis- and trans-3-Aminocyclohexanols by Reduction of β-Enaminoketones. Molecules 2012, 17, 151-162.

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