Molecules 2011, 16(8), 6883-6893; doi:10.3390/molecules16086883
Communication

High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach

Laboratoire de Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Universités d’Aix-Marseille I, II et III – CNRS, UMR 6264: Laboratoire Chimie Provence, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
* Author to whom correspondence should be addressed.
Received: 20 July 2011; in revised form: 5 August 2011 / Accepted: 8 August 2011 / Published: 12 August 2011
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Abstract: We report herein the synthesis of substituted 2-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)phenyl]-1-arylethanols, ethyl 3-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)-phenyl]-2-hydroxypropanoate and 2-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)benzyl]-2-hydroxy-acenaphthylen-1(2H)-one from the reactions of 4-[4-(chloromethyl)phenyl]-1,2-dimethyl-5-nitro-1H-imidazole with various aromatic carbonyl and a-carbonyl ester derivatives using tetrakis(dimethylamino)ethylene (TDAE) methodology.
Keywords: TDAE; 5-nitro-1H-imidazole; arylethanol; carbonyl derivatives

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MDPI and ACS Style

Juspin, T.; Zink, L.; Crozet, M.D.; Terme, T.; Vanelle, P. High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach. Molecules 2011, 16, 6883-6893.

AMA Style

Juspin T, Zink L, Crozet MD, Terme T, Vanelle P. High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach. Molecules. 2011; 16(8):6883-6893.

Chicago/Turabian Style

Juspin, Thierry; Zink, Laura; Crozet, Maxime D.; Terme, Thierry; Vanelle, Patrice. 2011. "High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach." Molecules 16, no. 8: 6883-6893.

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