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Molecules 2011, 16(8), 6883-6893; doi:10.3390/molecules16086883

High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach

Laboratoire de Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Universités d’Aix-Marseille I, II et III – CNRS, UMR 6264: Laboratoire Chimie Provence, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
Author to whom correspondence should be addressed.
Received: 20 July 2011 / Revised: 5 August 2011 / Accepted: 8 August 2011 / Published: 12 August 2011
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We report herein the synthesis of substituted 2-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)phenyl]-1-arylethanols, ethyl 3-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)-phenyl]-2-hydroxypropanoate and 2-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)benzyl]-2-hydroxy-acenaphthylen-1(2H)-one from the reactions of 4-[4-(chloromethyl)phenyl]-1,2-dimethyl-5-nitro-1H-imidazole with various aromatic carbonyl and a-carbonyl ester derivatives using tetrakis(dimethylamino)ethylene (TDAE) methodology.
Keywords: TDAE; 5-nitro-1H-imidazole; arylethanol; carbonyl derivatives TDAE; 5-nitro-1H-imidazole; arylethanol; carbonyl derivatives

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Juspin, T.; Zink, L.; Crozet, M.D.; Terme, T.; Vanelle, P. High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach. Molecules 2011, 16, 6883-6893.

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