Molecules 2011, 16(8), 6883-6893; doi:10.3390/molecules16086883
Communication

High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach

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Received: 20 July 2011; in revised form: 5 August 2011 / Accepted: 8 August 2011 / Published: 12 August 2011
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: We report herein the synthesis of substituted 2-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)phenyl]-1-arylethanols, ethyl 3-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)-phenyl]-2-hydroxypropanoate and 2-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)benzyl]-2-hydroxy-acenaphthylen-1(2H)-one from the reactions of 4-[4-(chloromethyl)phenyl]-1,2-dimethyl-5-nitro-1H-imidazole with various aromatic carbonyl and a-carbonyl ester derivatives using tetrakis(dimethylamino)ethylene (TDAE) methodology.
Keywords: TDAE; 5-nitro-1H-imidazole; arylethanol; carbonyl derivatives
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MDPI and ACS Style

Juspin, T.; Zink, L.; Crozet, M.D.; Terme, T.; Vanelle, P. High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach. Molecules 2011, 16, 6883-6893.

AMA Style

Juspin T, Zink L, Crozet MD, Terme T, Vanelle P. High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach. Molecules. 2011; 16(8):6883-6893.

Chicago/Turabian Style

Juspin, Thierry; Zink, Laura; Crozet, Maxime D.; Terme, Thierry; Vanelle, Patrice. 2011. "High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach." Molecules 16, no. 8: 6883-6893.

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