Next Article in Journal
Synthesis of Quinoxaline 1,4-di-N-Oxide Analogues and Crystal Structure of 2-Carbomethoxy-3-hydroxyquinoxaline-di-N-oxide
Previous Article in Journal
Cardanol-Based Materials as Natural Precursors for Olefin Metathesis
Molecules 2011, 16(8), 6883-6893; doi:10.3390/molecules16086883
Communication

High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach

, , ,  and *
Laboratoire de Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Universités d’Aix-Marseille I, II et III – CNRS, UMR 6264: Laboratoire Chimie Provence, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
* Author to whom correspondence should be addressed.
Received: 20 July 2011 / Revised: 5 August 2011 / Accepted: 8 August 2011 / Published: 12 August 2011
Download PDF [472 KB, uploaded 18 June 2014]   |  

Abstract

We report herein the synthesis of substituted 2-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)phenyl]-1-arylethanols, ethyl 3-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)-phenyl]-2-hydroxypropanoate and 2-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)benzyl]-2-hydroxy-acenaphthylen-1(2H)-one from the reactions of 4-[4-(chloromethyl)phenyl]-1,2-dimethyl-5-nitro-1H-imidazole with various aromatic carbonyl and a-carbonyl ester derivatives using tetrakis(dimethylamino)ethylene (TDAE) methodology.
Keywords: TDAE; 5-nitro-1H-imidazole; arylethanol; carbonyl derivatives TDAE; 5-nitro-1H-imidazole; arylethanol; carbonyl derivatives
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Juspin, T.; Zink, L.; Crozet, M.D.; Terme, T.; Vanelle, P. High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach. Molecules 2011, 16, 6883-6893.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert