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Molecules 2011, 16(8), 6883-6893; doi:10.3390/molecules16086883
Communication

High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach

, , ,  and *
Received: 20 July 2011 / Revised: 5 August 2011 / Accepted: 8 August 2011 / Published: 12 August 2011
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Abstract

We report herein the synthesis of substituted 2-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)phenyl]-1-arylethanols, ethyl 3-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)-phenyl]-2-hydroxypropanoate and 2-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)benzyl]-2-hydroxy-acenaphthylen-1(2H)-one from the reactions of 4-[4-(chloromethyl)phenyl]-1,2-dimethyl-5-nitro-1H-imidazole with various aromatic carbonyl and a-carbonyl ester derivatives using tetrakis(dimethylamino)ethylene (TDAE) methodology.
Keywords: TDAE; 5-nitro-1H-imidazole; arylethanol; carbonyl derivatives TDAE; 5-nitro-1H-imidazole; arylethanol; carbonyl derivatives
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Juspin, T.; Zink, L.; Crozet, M.D.; Terme, T.; Vanelle, P. High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach. Molecules 2011, 16, 6883-6893.

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