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Molecules 2011, 16(8), 6833-6843; doi:10.3390/molecules16086833
Article

The Use of Umbelliferone in the Synthesis of New Heterocyclic Compounds

1,2,* , 1, 1 and 1
1 Department of Chemical and Processing Engineering, Faculty of Engineering and Built Environment, University of Kebangsaan Malaysia, Bangi, Selangor 43600, Malaysia 2 Biotechnology Division, Applied Science Department, University of Technology, Baghdad 10066, Iraq
* Author to whom correspondence should be addressed.
Received: 11 July 2011 / Revised: 22 July 2011 / Accepted: 1 August 2011 / Published: 10 August 2011
(This article belongs to the Section Organic Synthesis)
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Abstract

New coumarin derivatives, namely 7-[(5-amino-1,3,4-thiadiazol-2-yl)methoxy]-2H-chromen-2-one (4), 5-[(2-oxo-2H-chromen-7-yloxy)methyl]-1,3,4-thiadiazol-2(3H)-one (5), 2-[2-(2-oxo-2H-chromen-7-yloxy)acetyl]-N-phenylhydrazinecarbothioamide (7), 7-[(5-(phenylamino)-1,3,4-thiadiazol-2-yl)methoxy]-2H-chromen-2-one (8) and 7-[(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)methoxy]-2H-chromen-2-one (9) were prepared starting from the natural compound umbelliferone (1). The newly synthesized compounds were characterized by elemental analysis and spectral studies (IR, 1H-NMR and 13C-NMR).
Keywords: coumarin; ethyl bromoacetate; phosphorous oxychloride; 1,3,4-thiadiazole; thiosemicarbazide; umbelliferone coumarin; ethyl bromoacetate; phosphorous oxychloride; 1,3,4-thiadiazole; thiosemicarbazide; umbelliferone
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Al-Amiery, A.A.; Musa, A.Y.; Kadhum, A.A.H.; Mohamad, A.B. The Use of Umbelliferone in the Synthesis of New Heterocyclic Compounds. Molecules 2011, 16, 6833-6843.

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