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Molecules 2011, 16(8), 6833-6843; doi:10.3390/molecules16086833
Article

The Use of Umbelliferone in the Synthesis of New Heterocyclic Compounds

1,2,* , 1, 1 and 1
Received: 11 July 2011; in revised form: 22 July 2011 / Accepted: 1 August 2011 / Published: 10 August 2011
(This article belongs to the Section Organic Synthesis)
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Abstract: New coumarin derivatives, namely 7-[(5-amino-1,3,4-thiadiazol-2-yl)methoxy]-2H-chromen-2-one (4), 5-[(2-oxo-2H-chromen-7-yloxy)methyl]-1,3,4-thiadiazol-2(3H)-one (5), 2-[2-(2-oxo-2H-chromen-7-yloxy)acetyl]-N-phenylhydrazinecarbothioamide (7), 7-[(5-(phenylamino)-1,3,4-thiadiazol-2-yl)methoxy]-2H-chromen-2-one (8) and 7-[(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)methoxy]-2H-chromen-2-one (9) were prepared starting from the natural compound umbelliferone (1). The newly synthesized compounds were characterized by elemental analysis and spectral studies (IR, 1H-NMR and 13C-NMR).
Keywords: coumarin; ethyl bromoacetate; phosphorous oxychloride; 1,3,4-thiadiazole; thiosemicarbazide; umbelliferone coumarin; ethyl bromoacetate; phosphorous oxychloride; 1,3,4-thiadiazole; thiosemicarbazide; umbelliferone
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Al-Amiery, A.A.; Musa, A.Y.; Kadhum, A.A.H.; Mohamad, A.B. The Use of Umbelliferone in the Synthesis of New Heterocyclic Compounds. Molecules 2011, 16, 6833-6843.

AMA Style

Al-Amiery AA, Musa AY, Kadhum AAH, Mohamad AB. The Use of Umbelliferone in the Synthesis of New Heterocyclic Compounds. Molecules. 2011; 16(8):6833-6843.

Chicago/Turabian Style

Al-Amiery, Ahmed A.; Musa, Ahmed Y.; Kadhum, Abdul Amir H.; Mohamad, Abu Bakar. 2011. "The Use of Umbelliferone in the Synthesis of New Heterocyclic Compounds." Molecules 16, no. 8: 6833-6843.



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