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Molecules 2011, 16(8), 6833-6843; doi:10.3390/molecules16086833

The Use of Umbelliferone in the Synthesis of New Heterocyclic Compounds

1
Department of Chemical and Processing Engineering, Faculty of Engineering and Built Environment, University of Kebangsaan Malaysia, Bangi, Selangor 43600, Malaysia
2
Biotechnology Division, Applied Science Department, University of Technology, Baghdad 10066, Iraq
*
Author to whom correspondence should be addressed.
Received: 11 July 2011 / Revised: 22 July 2011 / Accepted: 1 August 2011 / Published: 10 August 2011
(This article belongs to the Section Organic Synthesis)
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Abstract

New coumarin derivatives, namely 7-[(5-amino-1,3,4-thiadiazol-2-yl)methoxy]-2H-chromen-2-one (4), 5-[(2-oxo-2H-chromen-7-yloxy)methyl]-1,3,4-thiadiazol-2(3H)-one (5), 2-[2-(2-oxo-2H-chromen-7-yloxy)acetyl]-N-phenylhydrazinecarbothioamide (7), 7-[(5-(phenylamino)-1,3,4-thiadiazol-2-yl)methoxy]-2H-chromen-2-one (8) and 7-[(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)methoxy]-2H-chromen-2-one (9) were prepared starting from the natural compound umbelliferone (1). The newly synthesized compounds were characterized by elemental analysis and spectral studies (IR, 1H-NMR and 13C-NMR).
Keywords: coumarin; ethyl bromoacetate; phosphorous oxychloride; 1,3,4-thiadiazole; thiosemicarbazide; umbelliferone coumarin; ethyl bromoacetate; phosphorous oxychloride; 1,3,4-thiadiazole; thiosemicarbazide; umbelliferone
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Al-Amiery, A.A.; Musa, A.Y.; Kadhum, A.A.H.; Mohamad, A.B. The Use of Umbelliferone in the Synthesis of New Heterocyclic Compounds. Molecules 2011, 16, 6833-6843.

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