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The Use of Umbelliferone in the Synthesis of New Heterocyclic Compounds
Department of Chemical and Processing Engineering, Faculty of Engineering and Built Environment, University of Kebangsaan Malaysia, Bangi, Selangor 43600, Malaysia
Biotechnology Division, Applied Science Department, University of Technology, Baghdad 10066, Iraq
* Author to whom correspondence should be addressed.
Received: 11 July 2011; in revised form: 22 July 2011 / Accepted: 1 August 2011 / Published: 10 August 2011
Abstract: New coumarin derivatives, namely 7-[(5-amino-1,3,4-thiadiazol-2-yl)methoxy]-2H-chromen-2-one (4), 5-[(2-oxo-2H-chromen-7-yloxy)methyl]-1,3,4-thiadiazol-2(3H)-one (5), 2-[2-(2-oxo-2H-chromen-7-yloxy)acetyl]-N-phenylhydrazinecarbothioamide (7), 7-[(5-(phenylamino)-1,3,4-thiadiazol-2-yl)methoxy]-2H-chromen-2-one (8) and 7-[(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)methoxy]-2H-chromen-2-one (9) were prepared starting from the natural compound umbelliferone (1). The newly synthesized compounds were characterized by elemental analysis and spectral studies (IR, 1H-NMR and 13C-NMR).
Keywords: coumarin; ethyl bromoacetate; phosphorous oxychloride; 1,3,4-thiadiazole; thiosemicarbazide; umbelliferone
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Al-Amiery, A.A.; Musa, A.Y.; Kadhum, A.A.H.; Mohamad, A.B. The Use of Umbelliferone in the Synthesis of New Heterocyclic Compounds. Molecules 2011, 16, 6833-6843.
Al-Amiery AA, Musa AY, Kadhum AAH, Mohamad AB. The Use of Umbelliferone in the Synthesis of New Heterocyclic Compounds. Molecules. 2011; 16(8):6833-6843.
Al-Amiery, Ahmed A.; Musa, Ahmed Y.; Kadhum, Abdul Amir H.; Mohamad, Abu Bakar. 2011. "The Use of Umbelliferone in the Synthesis of New Heterocyclic Compounds." Molecules 16, no. 8: 6833-6843.