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Molecules 2011, 16(8), 6677-6683; doi:10.3390/molecules16086677

Fast Method for Synthesis of Alkyl and Aryl-N-Methylnitrones

1, 2, 3 and 1,*
1 Chemistry Department, Faculty of Science, Gazi University, Ankara 06500, Turkey 2 Chemistry Department, Faculty of Science, Çankırı Karatekin University, Çankırı 18100, Turkey 3 Chemistry Department, Faculty of Science and Arts, Hitit University, Çorum 19030, Turkey
* Author to whom correspondence should be addressed.
Received: 20 June 2011 / Revised: 18 July 2011 / Accepted: 19 July 2011 / Published: 8 August 2011
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A simple, fast, efficient and eco-friendly procedure was developed for the synthesis of alkyl and aryl-N-methylnitrones. The corresponding nitrones of aromatic aldehydes, aliphatic aldehydes and alicyclic carbonyl compounds were prepared from N-methylhydroxylamine hydrochloride and Na2CO3-Na2SO4 by simply grinding at room temperature without using solvent.
Keywords: nitrone; grinding; solid-phase synthesis; solventless nitrone; grinding; solid-phase synthesis; solventless
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yavuz, S.; Ozkan, H.; Colak, N.; Yildirir, Y. Fast Method for Synthesis of Alkyl and Aryl-N-Methylnitrones. Molecules 2011, 16, 6677-6683.

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