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Fast Method for Synthesis of Alkyl and Aryl-N-Methylnitrones
Chemistry Department, Faculty of Science, Gazi University, Ankara 06500, Turkey
Chemistry Department, Faculty of Science, Çankırı Karatekin University, Çankırı 18100, Turkey
Chemistry Department, Faculty of Science and Arts, Hitit University, Çorum 19030, Turkey
* Author to whom correspondence should be addressed.
Received: 20 June 2011; in revised form: 18 July 2011 / Accepted: 19 July 2011 / Published: 8 August 2011
Abstract: A simple, fast, efficient and eco-friendly procedure was developed for the synthesis of alkyl and aryl-N-methylnitrones. The corresponding nitrones of aromatic aldehydes, aliphatic aldehydes and alicyclic carbonyl compounds were prepared from N-methylhydroxylamine hydrochloride and Na2CO3-Na2SO4 by simply grinding at room temperature without using solvent.
Keywords: nitrone; grinding; solid-phase synthesis; solventless
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Yavuz, S.; Ozkan, H.; Colak, N.; Yildirir, Y. Fast Method for Synthesis of Alkyl and Aryl-N-Methylnitrones. Molecules 2011, 16, 6677-6683.
Yavuz S, Ozkan H, Colak N, Yildirir Y. Fast Method for Synthesis of Alkyl and Aryl-N-Methylnitrones. Molecules. 2011; 16(8):6677-6683.
Yavuz, Serkan; Ozkan, Hamdi; Colak, Naki; Yildirir, Yilmaz. 2011. "Fast Method for Synthesis of Alkyl and Aryl-N-Methylnitrones." Molecules 16, no. 8: 6677-6683.