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Molecules 2011, 16(8), 6677-6683; doi:10.3390/molecules16086677

Fast Method for Synthesis of Alkyl and Aryl-N-Methylnitrones

1, 2, 3 and 1,*
1 Chemistry Department, Faculty of Science, Gazi University, Ankara 06500, Turkey 2 Chemistry Department, Faculty of Science, Çankırı Karatekin University, Çankırı 18100, Turkey 3 Chemistry Department, Faculty of Science and Arts, Hitit University, Çorum 19030, Turkey
* Author to whom correspondence should be addressed.
Received: 20 June 2011 / Revised: 18 July 2011 / Accepted: 19 July 2011 / Published: 8 August 2011
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A simple, fast, efficient and eco-friendly procedure was developed for the synthesis of alkyl and aryl-N-methylnitrones. The corresponding nitrones of aromatic aldehydes, aliphatic aldehydes and alicyclic carbonyl compounds were prepared from N-methylhydroxylamine hydrochloride and Na2CO3-Na2SO4 by simply grinding at room temperature without using solvent.
Keywords: nitrone; grinding; solid-phase synthesis; solventless nitrone; grinding; solid-phase synthesis; solventless
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Yavuz, S.; Ozkan, H.; Colak, N.; Yildirir, Y. Fast Method for Synthesis of Alkyl and Aryl-N-Methylnitrones. Molecules 2011, 16, 6677-6683.

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