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Molecules 2011, 16(7), 6148-6164; doi:10.3390/molecules16076148
Article

Physicochemical Characteristics and Immunomodulatory Activities of Three Polysaccharide-Protein Complexes of Longan Pulp

1,2, 1, 1,* , 3, 1, 1 and 1
Received: 26 May 2011 / Revised: 27 June 2011 / Accepted: 14 July 2011 / Published: 21 July 2011
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Abstract

Three polysaccharide-protein complexes of longan pulp (LP1-3) were isolated in this work. Their physicochemical characteristics and immunomodulatory effects on splenocytes, natural killer (NK) cells and macrophages in vitro were investigated. The carbohydrate portions of LP1-3 were principally composed of glucose, arabinose and mannose. LP3 displayed the maximal moisture absorption, and the thermal stability of LP2 was obviously higher than that of LP1 and LP3. All of them showed the characteristic polysaccharide and protein bands in the Fourier Transform Infrared (FTIR) spectrum. For a certain dose, all the fractions could significantly stimulate splenocyte proliferation, macrophage phagocytosis against neutral red, and NK cell cytotoxicity against YAC-1 lymphoma cell (P < 0.05). The results demonstrated that the polysaccharide-protein complexes of longan pulp have medical potential as immunotherapeutic adjuvants due to their immunomodulatory activities.
Keywords: longan; pulp; polysaccharide-protein complex; physicochemical characteristic; immunomodulatory activity longan; pulp; polysaccharide-protein complex; physicochemical characteristic; immunomodulatory activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yi, Y.; Liao, S.T.; Zhang, M.W.; Shi, J.; Zhang, R.F.; Deng, Y.Y.; Wei, Z.C. Physicochemical Characteristics and Immunomodulatory Activities of Three Polysaccharide-Protein Complexes of Longan Pulp. Molecules 2011, 16, 6148-6164.

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