Next Article in Journal
Synthesis and Biological Evaluation of Novel 99mTc-Labelled Bisphosphonates as Superior Bone Imaging Agents
Previous Article in Journal
Synthesis and E/Z Configuration Determination of Novel Derivatives of 3-Aryl-2-(benzothiazol-2'-ylthio) Acrylonitrile, 3-(Benzothiazol-2'-ylthio)-4-(furan-2''-yl)-3-buten-2-one and 2-(1-(Furan-2''-yl)-3'-oxobut-1''-en-2-ylthio)-3-phenylquinazolin-4(3H)-one
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2011, 16(7), 6148-6164; doi:10.3390/molecules16076148

Physicochemical Characteristics and Immunomodulatory Activities of Three Polysaccharide-Protein Complexes of Longan Pulp

1
Ministry of Agriculture/Bio-tech Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China
2
College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
3
Guleph Food Research Center, Agriculture and Agri-Food Canada, 93 Stone Road West, Guelph, ON N1G5C9, Canada
*
Author to whom correspondence should be addressed.
Received: 26 May 2011 / Revised: 27 June 2011 / Accepted: 14 July 2011 / Published: 21 July 2011
Download PDF [406 KB, uploaded 18 June 2014]

Abstract

Three polysaccharide-protein complexes of longan pulp (LP1-3) were isolated in this work. Their physicochemical characteristics and immunomodulatory effects on splenocytes, natural killer (NK) cells and macrophages in vitro were investigated. The carbohydrate portions of LP1-3 were principally composed of glucose, arabinose and mannose. LP3 displayed the maximal moisture absorption, and the thermal stability of LP2 was obviously higher than that of LP1 and LP3. All of them showed the characteristic polysaccharide and protein bands in the Fourier Transform Infrared (FTIR) spectrum. For a certain dose, all the fractions could significantly stimulate splenocyte proliferation, macrophage phagocytosis against neutral red, and NK cell cytotoxicity against YAC-1 lymphoma cell (P < 0.05). The results demonstrated that the polysaccharide-protein complexes of longan pulp have medical potential as immunotherapeutic adjuvants due to their immunomodulatory activities.
Keywords: longan; pulp; polysaccharide-protein complex; physicochemical characteristic; immunomodulatory activity longan; pulp; polysaccharide-protein complex; physicochemical characteristic; immunomodulatory activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Yi, Y.; Liao, S.T.; Zhang, M.W.; Shi, J.; Zhang, R.F.; Deng, Y.Y.; Wei, Z.C. Physicochemical Characteristics and Immunomodulatory Activities of Three Polysaccharide-Protein Complexes of Longan Pulp. Molecules 2011, 16, 6148-6164.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top