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Molecules 2011, 16(7), 5402-5421; doi:10.3390/molecules16075402

Keeping an Eye on Myocilin: A Complex Molecule Associated with Primary Open-Angle Glaucoma Susceptibility

1
Laboratory of Human Genetics, Center for Molecular Biology and Genetic Engineering (CBMEG), University of Campinas (UNICAMP), Campinas-SP 13083-875, Brazil
2
Department of Ophthalmology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas-SP 13083-888, Brazil
3
Department of Chemistry and Nanobiotechnology, Fluorotronics, Inc., San Diego, CA 92081, USA
*
Author to whom correspondence should be addressed.
Received: 16 June 2011 / Accepted: 21 June 2011 / Published: 27 June 2011
(This article belongs to the Section Molecular Diversity)
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Abstract

MYOC encodes a secretary glycoprotein of 504 amino acids named myocilin. MYOC is the first gene to be linked to juvenile open-angle glaucoma (JOAG) and some forms of adult-onset primary open-angle glaucoma (POAG). The gene was identified as an up-regulated molecule in cultured trabecular meshwork (TM) cells after treatment with dexamethasone and was originally referred to as trabecular meshwork-inducible glucocorticoid response (TIGR). Elevated intraocular pressure (IOP), due to decreased aqueous outflow, is the strongest known risk factor for POAG. Increasing evidence showed that the modulation of the wild-type (wt) myocilin protein expression is not causative of glaucoma while some misfolded and self-assembly aggregates of mutated myocilin may be associated with POAG in related or unrelated populations. The etiology of the disease remains unclear. Consequently, a better understanding of the molecular mechanisms underlyingPOAG is required to obtain early diagnosis, avoid potential disease progression, and develop new therapeutic strategies. In the present study, we review and discuss the most relevant studies regarding structural characterizations, expressions, molecular interactions, putative functions of MYOC gene and/or its corresponding protein in POAG etiology.
Keywords: glaucoma; blindness; myocilin; gene variants; protein folding; molecular aggregation glaucoma; blindness; myocilin; gene variants; protein folding; molecular aggregation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Menaa, F.; Braghini, C.A.; Vasconcellos, J.P.C.D.; Menaa, B.; Costa, V.P.; Figueiredo, E.S.D.; Melo, M.B.D. Keeping an Eye on Myocilin: A Complex Molecule Associated with Primary Open-Angle Glaucoma Susceptibility. Molecules 2011, 16, 5402-5421.

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