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Molecules 2011, 16(6), 4539-4548; doi:10.3390/molecules16064539

Phytochemical and Cytotoxic Investigations of Curcuma mangga Rhizomes

1
Institute of Biological Sciences, University of Malaysia, 50603 Kuala Lumpur, Malaysia
2
International University College of Nursing, L1.10, Cova Square, Jalan Teknologi, Kota Damansara, PJU5, 47810 Petaling Jaya, Selangor Darul Ehsan, Malaysia
3
Centre for Foundation Studies in Science, University of Malaysia, 50603 Kuala Lumpur, Malaysia
4
Research Institute of Natural Products for Drug Discovery (RiND), Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia
*
Author to whom correspondence should be addressed.
Received: 29 March 2011 / Revised: 18 April 2011 / Accepted: 20 April 2011 / Published: 31 May 2011
(This article belongs to the Section Natural Products)
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Abstract

Investigations on the cytotoxic effects of the crude methanol and fractionated extracts (hexane, ethyl acetate) C. mangga against six human cancer cell lines, namely the hormone-dependent breast cell line (MCF-7), nasopharyngeal epidermoid cell line (KB), lung cell line (A549), cervical cell line (Ca Ski), colon cell lines (HCT 116 and HT-29), and one non-cancer human fibroblast cell line (MRC-5) were conducted using an in-vitro neutral red cytotoxicity assay. The crude methanol and fractionated extracts (hexane and ethyl acetate) displayed good cytotoxic effects against MCF-7, KB, A549, Ca Ski and HT-29 cell lines, but exerted no damage on the MRC-5 line. Chemical investigation from the hexane and ethyl acetate fractions resulted in the isolation of seven pure compounds, namely (E)-labda-8(17),12-dien-15,16-dial (1), (E)-15,16-bisnor-labda-8(17),11-dien-13-on (2), zerumin A (3), β-sitosterol, curcumin, demethoxycurcumin and bis-demethoxycurcumin. Compounds 1 and 3 exhibited high cytotoxic effects against all six selected cancer cell lines, while compounds 2 showed no anti-proliferative activity on the tested cell lines. Compound 1 also demonstrated strong cytotoxicity against the normal cell line MRC-5. This paper reports for the first time the cytotoxic activities of C. mangga extracts on KB, A549, Ca Ski, HT-29 and MRC-5, and the occurrence of compound 2 and 3 in C. mangga.
Keywords: Curcuma mangga; Zingiberaceae; labdane diterpene; neutral red cytotoxicity assay; cancer cell lines Curcuma mangga; Zingiberaceae; labdane diterpene; neutral red cytotoxicity assay; cancer cell lines
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Malek, S.N.A.; Lee, G.S.; Hong, S.L.; Yaacob, H.; Wahab, N.A.; Faizal Weber, J.-F.; Shah, S.A.A. Phytochemical and Cytotoxic Investigations of Curcuma mangga Rhizomes. Molecules 2011, 16, 4539-4548.

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