Molecules 2011, 16(5), 4305-4317; doi:10.3390/molecules16054305
Article

Synthesis, and Antitumor Activity of Some N1-(Coumarin-7-yl) Amidrazones and Related Congeners

Mohammad S. Mustafa 1 , Mustafa M. El-Abadelah 1 , Malek A. Zihlif 2 , Randa G. Naffa 3  and Mohammad S. Mubarak 1,* email
1 Department of Chemistry, The University of Jordan, Amman 11942, Jordan 2 Department of Pharmacology, Faculty of Medicine, The University of Jordan, Amman 11942, Jordan 3 Molecular Biology Research Laboratory, Faculty of Medicine, The University of Jordan, Amman 11942, Jordan
* Author to whom correspondence should be addressed.
Received: 8 April 2011; in revised form: 9 May 2011 / Accepted: 11 May 2011 / Published: 24 May 2011
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Abstract: A series of new N1-(coumarin-7-yl)amidrazones incorporating N-piperazines and related congeners were synthesized by reacting the hydrazonoyl chloride derived from 7-amino-4-methylcoumarin with the appropriate piperazines. The chemical structures of the newly prepared compounds were supported by elemental analyses, 1H-NMR, 13C-NMR, and ESI-HRMS spectral data. The antitumor activity of the newly synthesized compounds was evaluated. Among all the compounds tested, 7-{2-[1-(4-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-yl)piperazin-1-yl)-2-oxopropylidene]hydrazinyl}-4-methyl-2H-chromen-2-one (3n) was the most potent against MCF-7 and K562 cells, with IC50 values of 20.2 and 9.3 μM, respectively.
Keywords: 7-aminocoumarins; N-(coumarin-7-yl)hydrazonoyl chloride; 1-piperazinyl amidrazones; nitrileimine; antitumor activity

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Cite This Article

MDPI and ACS Style

Mustafa, M.S.; El-Abadelah, M.M.; Zihlif, M.A.; Naffa, R.G.; Mubarak, M.S. Synthesis, and Antitumor Activity of Some N1-(Coumarin-7-yl) Amidrazones and Related Congeners. Molecules 2011, 16, 4305-4317.

AMA Style

Mustafa MS, El-Abadelah MM, Zihlif MA, Naffa RG, Mubarak MS. Synthesis, and Antitumor Activity of Some N1-(Coumarin-7-yl) Amidrazones and Related Congeners. Molecules. 2011; 16(5):4305-4317.

Chicago/Turabian Style

Mustafa, Mohammad S.; El-Abadelah, Mustafa M.; Zihlif, Malek A.; Naffa, Randa G.; Mubarak, Mohammad S. 2011. "Synthesis, and Antitumor Activity of Some N1-(Coumarin-7-yl) Amidrazones and Related Congeners." Molecules 16, no. 5: 4305-4317.

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