Molecules 2011, 16(5), 4305-4317; doi:10.3390/molecules16054305
Article

Synthesis, and Antitumor Activity of Some N1-(Coumarin-7-yl) Amidrazones and Related Congeners

Received: 8 April 2011; in revised form: 9 May 2011 / Accepted: 11 May 2011 / Published: 24 May 2011
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A series of new N1-(coumarin-7-yl)amidrazones incorporating N-piperazines and related congeners were synthesized by reacting the hydrazonoyl chloride derived from 7-amino-4-methylcoumarin with the appropriate piperazines. The chemical structures of the newly prepared compounds were supported by elemental analyses, 1H-NMR, 13C-NMR, and ESI-HRMS spectral data. The antitumor activity of the newly synthesized compounds was evaluated. Among all the compounds tested, 7-{2-[1-(4-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-yl)piperazin-1-yl)-2-oxopropylidene]hydrazinyl}-4-methyl-2H-chromen-2-one (3n) was the most potent against MCF-7 and K562 cells, with IC50 values of 20.2 and 9.3 μM, respectively.
Keywords: 7-aminocoumarins; N-(coumarin-7-yl)hydrazonoyl chloride; 1-piperazinyl amidrazones; nitrileimine; antitumor activity
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MDPI and ACS Style

Mustafa, M.S.; El-Abadelah, M.M.; Zihlif, M.A.; Naffa, R.G.; Mubarak, M.S. Synthesis, and Antitumor Activity of Some N1-(Coumarin-7-yl) Amidrazones and Related Congeners. Molecules 2011, 16, 4305-4317.

AMA Style

Mustafa MS, El-Abadelah MM, Zihlif MA, Naffa RG, Mubarak MS. Synthesis, and Antitumor Activity of Some N1-(Coumarin-7-yl) Amidrazones and Related Congeners. Molecules. 2011; 16(5):4305-4317.

Chicago/Turabian Style

Mustafa, Mohammad S.; El-Abadelah, Mustafa M.; Zihlif, Malek A.; Naffa, Randa G.; Mubarak, Mohammad S. 2011. "Synthesis, and Antitumor Activity of Some N1-(Coumarin-7-yl) Amidrazones and Related Congeners." Molecules 16, no. 5: 4305-4317.

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