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Molecules 2011, 16(5), 3580-3596; doi:10.3390/molecules16053580

Synthesis of Some Phenylpropanoid Glycosides (PPGs) and Their Acetylcholinesterase/Xanthine Oxidase Inhibitory Activities

1
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
2
School of Pharmacy, Shihezi University, Shihezi 832002, China
3
Key Laboratory of Phytomedicine Resources & Modernization of TCM of Ministry of Education, Shihezi 832002, China
4
Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China
*
Author to whom correspondence should be addressed.
Received: 16 March 2011 / Revised: 25 April 2011 / Accepted: 26 April 2011 / Published: 28 April 2011
(This article belongs to the Section Medicinal Chemistry)
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Abstract

In this research, three categories of phenylpropanoid glycosides (PPGs) were designed and synthesized with PPGs isolated from Rhodiola rosea L. as lead compounds. Their inhibitory abilities toward acetylcholinesterase (AChE) and xanthine oxidase (XOD) were also tested. Some of the synthetic PPGs exhibited excellent enzyme inhibitory abilities.
Keywords: phenylpropanoid glycosides; Rhodiola rosea L.; acetylcholinesterase/xanthine oxidase inhibitory activity phenylpropanoid glycosides; Rhodiola rosea L.; acetylcholinesterase/xanthine oxidase inhibitory activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Li, X.-D.; Kang, S.-T.; Li, G.-Y.; Li, X.; Wang, J.-H. Synthesis of Some Phenylpropanoid Glycosides (PPGs) and Their Acetylcholinesterase/Xanthine Oxidase Inhibitory Activities. Molecules 2011, 16, 3580-3596.

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