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Molecules 2011, 16(4), 3433-3443; doi:10.3390/molecules16043433
Article

Antioxidant, Total Phenolic Content and Cytotoxicity Evaluation of Selected Malaysian Plants

1,* , 2
, 3
, 4
, 4
 and 1
1 Department of Biological Science, Faculty of Biosciences and Bioengineering, University of Technology Malaysia, 81310, UTM Skudai, Johor, Malaysia 2 Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia 3 Metabolites Profiling Laboratory, Chemical Engineering Pilot Plant, University Technology Malaysia, 81310, UTM Skudai, Johor, Malaysia 4 Tissue Culture Research Laboratory, Centre of Synthesis and Chemical Biology, Institute of Science, University Technology MARA, 40450, Shah Alam, Malaysia
* Author to whom correspondence should be addressed.
Received: 28 February 2011 / Revised: 2 April 2011 / Accepted: 8 April 2011 / Published: 21 April 2011
(This article belongs to the Section Metabolites)
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Abstract

Aqueous and ethanol extracts of different traditional Malaysian plants (Polygonum minus, Andrographis paniculata, Curcuma xanthorrhiza, Momordica charantia and Strobilanthes crispus) were evaluated for their antioxidant properties, total phenolic content and cytotoxic activity. Antioxidant activity was evaluated by using 1,1-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays. The results showed that ethanol extracts contain high antioxidant activities compared to aqueous extracts. The findings exhibited a strong correlation between antioxidant activity and the total phenol contents. In addition, all the plant extracts showed non-toxic effects against a normal human lung fibroblast cell line (Hs888Lu). Although traditionally aqueous extracts are used, we determined that ethanol extracts usually achieved better activity in the assays.
Keywords: antioxidant activity; total phenolic content; cytotoxicity; Malaysian plants antioxidant activity; total phenolic content; cytotoxicity; Malaysian plants
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Qader, S.W.; Abdulla, M.A.; Chua, L.S.; Najim, N.; Zain, M.M.; Hamdan, S. Antioxidant, Total Phenolic Content and Cytotoxicity Evaluation of Selected Malaysian Plants. Molecules 2011, 16, 3433-3443.

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