Molecules 2011, 16(4), 3360-3370; doi:10.3390/molecules16043360
Article

Antitussive Activity of Pseudostellaria heterophylla (Miq.) Pax Extracts and Improvement in Lung Function via Adjustment of Multi-Cytokine Levels

Wensheng Pangemail, Siding Linemail, Qiwen Daiemail, Hongcheng Zhangemail and Juan Hu* email
School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, 350108, China
* Author to whom correspondence should be addressed.
Received: 7 February 2011; in revised form: 28 March 2011 / Accepted: 31 March 2011 / Published: 19 April 2011
(This article belongs to the Section Natural Products)
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Abstract: Pseudostellaria heterophylla (Miq.) Pax is one of the most widespread herbal and healthcare products in China. Extensive clinical use has shown that it has functions which “strengthens qi and generates saliva, moistens the lung and relieves cough”. The ethyl acetate fraction extracted from the roots of the plant Pseudostellaria heterophylla exhibited a dose-dependent antitussive effect between 100 to 500 mg/kg. At a dose of 400 mg/kg, the ethyl acetate fraction treatment markedly prolonged the cough latent period and reduced the number of coughs in a guinea pig model induced by citric acid. Fall lung airway resistance, rise in dynamic lung compliance, decreased serum levels of IL-8, GM-CSF, TNF-α, and ET-1 in rat model of stable phase chronic obstructive pulmonary disease induced by cigarette smoke exposure were also observed. These results suggest that ethyl acetate fraction has antitussive activity related to its improvement in lung function via attenuation of airway inflammation by adjustment of multi-cytokine levels.
Keywords: Pseudostellaria heterophylla (Miq.) Pax; extracts; antitussive activity; improvement lung function; multi-cytokine adjusting

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MDPI and ACS Style

Pang, W.; Lin, S.; Dai, Q.; Zhang, H.; Hu, J. Antitussive Activity of Pseudostellaria heterophylla (Miq.) Pax Extracts and Improvement in Lung Function via Adjustment of Multi-Cytokine Levels. Molecules 2011, 16, 3360-3370.

AMA Style

Pang W, Lin S, Dai Q, Zhang H, Hu J. Antitussive Activity of Pseudostellaria heterophylla (Miq.) Pax Extracts and Improvement in Lung Function via Adjustment of Multi-Cytokine Levels. Molecules. 2011; 16(4):3360-3370.

Chicago/Turabian Style

Pang, Wensheng; Lin, Siding; Dai, Qiwen; Zhang, Hongcheng; Hu, Juan. 2011. "Antitussive Activity of Pseudostellaria heterophylla (Miq.) Pax Extracts and Improvement in Lung Function via Adjustment of Multi-Cytokine Levels." Molecules 16, no. 4: 3360-3370.

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