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Molecules 2011, 16(4), 3351-3359; doi:10.3390/molecules16043351
Article

Three New Oblongolides from Phomopsis sp. XZ-01, an Endophytic Fungus from Camptotheca acuminate

1,†,* , 1,†
,
2
,
3
,
1
,
1
,
1
 and
1,*
1 School of Pharmaceutical Sciences, Xiamen University, 422 South Siming Road, Xiamen, Fujian 361005, China 2 Institute of Life Sciences, Fuzhou University, No.2 Xueyuan Rd., University Town, Fuzhou, Fujian 350108, China 3 School of Life Sciences, Xiamen University, Fujian 361005, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 17 March 2011 / Revised: 1 April 2011 / Accepted: 2 April 2011 / Published: 19 April 2011
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Abstract

Four new metabolites, including three new oblongolides named C1, P1, and X1 (1-3) and 6-hydroxyphomodiol (10), along with eight known compounds – oblongolides B (4), C (5), D (6), O (7), P (8) and U (9), (3R,4aR,5S,6R)-6-hydroxy-5-methylramulosin (11), and (3R)-5-methylmellein (12) – were isolated from the endophytic fungal strain Phomopsis sp. XZ-01 of Camptotheca acuminate. Their structures were elucidated by spectroscopic analyses, including 1H- and 13C-NMR, 2D NMR (HSQC, HMBC, 1H-1H COSY and NOESY) and HR-FT-MS. Cytotoxic activities of these compounds were evaluated. Some of them showed weak selective activities.
Keywords: Camptotheca acuminate; endophytic fungus; Phomopsis sp. XZ-01; oblongolides; new metabolites Camptotheca acuminate; endophytic fungus; Phomopsis sp. XZ-01; oblongolides; new metabolites
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Lin, T.; Wang, G.H.; Lin, X.; Hu, Z.Y.; Chen, Q.C.; Xu, Y.; Zhang, X.K.; Chen, H.F. Three New Oblongolides from Phomopsis sp. XZ-01, an Endophytic Fungus from Camptotheca acuminate. Molecules 2011, 16, 3351-3359.

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