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Three New Oblongolides from Phomopsis sp. XZ-01, an Endophytic Fungus from Camptotheca acuminate
School of Pharmaceutical Sciences, Xiamen University, 422 South Siming Road, Xiamen, Fujian 361005, China
Institute of Life Sciences, Fuzhou University, No.2 Xueyuan Rd., University Town, Fuzhou, Fujian 350108, China
School of Life Sciences, Xiamen University, Fujian 361005, China
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 17 March 2011; in revised form: 1 April 2011 / Accepted: 2 April 2011 / Published: 19 April 2011
Abstract: Four new metabolites, including three new oblongolides named C1, P1, and X1 (1-3) and 6-hydroxyphomodiol (10), along with eight known compounds – oblongolides B (4), C (5), D (6), O (7), P (8) and U (9), (3R,4aR,5S,6R)-6-hydroxy-5-methylramulosin (11), and (3R)-5-methylmellein (12) – were isolated from the endophytic fungal strain Phomopsis sp. XZ-01 of Camptotheca acuminate. Their structures were elucidated by spectroscopic analyses, including 1H- and 13C-NMR, 2D NMR (HSQC, HMBC, 1H-1H COSY and NOESY) and HR-FT-MS. Cytotoxic activities of these compounds were evaluated. Some of them showed weak selective activities.
Keywords: Camptotheca acuminate; endophytic fungus; Phomopsis sp. XZ-01; oblongolides; new metabolites
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Lin, T.; Wang, G.H.; Lin, X.; Hu, Z.Y.; Chen, Q.C.; Xu, Y.; Zhang, X.K.; Chen, H.F. Three New Oblongolides from Phomopsis sp. XZ-01, an Endophytic Fungus from Camptotheca acuminate. Molecules 2011, 16, 3351-3359.
Lin T, Wang GH, Lin X, Hu ZY, Chen QC, Xu Y, Zhang XK, Chen HF. Three New Oblongolides from Phomopsis sp. XZ-01, an Endophytic Fungus from Camptotheca acuminate. Molecules. 2011; 16(4):3351-3359.
Lin, Ting; Wang, Guang Hui; Lin, Xiang; Hu, Zhi Yu; Chen, Quan Cheng; Xu, Yang; Zhang, Xiao Kun; Chen, Hai Feng. 2011. "Three New Oblongolides from Phomopsis sp. XZ-01, an Endophytic Fungus from Camptotheca acuminate." Molecules 16, no. 4: 3351-3359.