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Molecules 2011, 16(4), 3252-3314; doi:10.3390/molecules16043252

From Polymer to Small Organic Molecules: A Tight Relationship between Radical Chemistry and Solid-Phase Organic Synthesis

Department of Chemical Core Technologies, Nerviano Medical Sciences S.r.l., V.le Pasteur, 10, 20014, Nerviano (MI), Italy
Author to whom correspondence should be addressed.
Received: 8 March 2011 / Revised: 28 March 2011 / Accepted: 11 April 2011 / Published: 18 April 2011
(This article belongs to the Special Issue Diversity Oriented Synthesis)
Download PDF [688 KB, 18 June 2014; original version 18 June 2014]


Since Gomberg’s discovery of radicals as chemical entities, the interest around them has increased through the years. Nowadays, radical chemistry is used in the synthesis of 75% of all polymers, inevitably establishing a close relationship with Solid-Phase Organic Synthesis. More recently, the interest of organic chemists has shifted towards the application of usual “in-solution” radical chemistry to the solid-phase, ranging from the use of supported reagents for radical reactions, to the development of methodologies for the synthesis of small molecules or potential libraries. The aim of this review is to put in perspective radical chemistry, moving it away from its origin as a synthetic means for solid supports, to becoming a useful tool for the synthesis of small molecules.
Keywords: radical; solid-phase; SPS; polymer-assisted synthesis; polymer-supported reagents radical; solid-phase; SPS; polymer-assisted synthesis; polymer-supported reagents
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Mirizzi, D.; Pulici, M. From Polymer to Small Organic Molecules: A Tight Relationship between Radical Chemistry and Solid-Phase Organic Synthesis. Molecules 2011, 16, 3252-3314.

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