Abstract: A new abietene diterpene, kaempfolienol (5S,6S,7S,9S,10S,11R,13S-abiet-8(14)-enepenta-6,7,9,11,13-ol, 1), was isolated from a rhizome extract of Kaempferia angustifolia Rosc. along with the known compounds crotepoxide, boesenboxide, zeylenol, 2′-hydroxy-4,4′,6′-trimethoxychalcone, (24S)-24-methyl-5α-lanosta-9(11),25-dien-3β-ol, β-sitosterol and β-sitosterol-3-O-β-D-glucopyranoside. The structures of all compounds were elucidated on the basis of mass spectroscopic and NMR data. Zeylenol (2), the major constituent of the plant, was derivatized into diacetate, triacetate and epoxide derivatives through standard organic reactions. The cytotoxic activity of compounds 1, 2 and the zeylenol derivatives was evaluated against the HL-60, MCF-7, HT-29 and HeLa cell lines.
Keywords: Kaempferia angustifolia; abietene diterpene; kaempfolienol; zeylenol; cytotoxic
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Tang, S.W.; Sukari, M.A.; Rahmani, M.; Lajis, N.H.; Ali, A.M. A New Abietene Diterpene and Other Constituents from Kaempferia angustifolia Rosc.. Molecules 2011, 16, 3018-3028.
Tang SW, Sukari MA, Rahmani M, Lajis NH, Ali AM. A New Abietene Diterpene and Other Constituents from Kaempferia angustifolia Rosc.. Molecules. 2011; 16(4):3018-3028.
Tang, Sook Wah; Sukari, Mohd Aspollah; Rahmani, Mawardi; Lajis, Nordin Hj.; Ali, Abdul Manaf. 2011. "A New Abietene Diterpene and Other Constituents from Kaempferia angustifolia Rosc.." Molecules 16, no. 4: 3018-3028.