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Molecules 2011, 16(4), 3018-3028; doi:10.3390/molecules16043018
Article

A New Abietene Diterpene and Other Constituents from Kaempferia angustifolia Rosc.

1, 1,* , 1, 1 and 2
1 Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia 2 Universiti Sultan Zainal Abidin, Kampus Kota, Jalan Sultan Mahmud, 20400 Kuala Terengganu, Malaysia
* Author to whom correspondence should be addressed.
Received: 16 March 2011 / Revised: 1 April 2011 / Accepted: 2 April 2011 / Published: 7 April 2011
(This article belongs to the Section Metabolites)
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Abstract

A new abietene diterpene, kaempfolienol (5S,6S,7S,9S,10S,11R,13S-abiet-8(14)-enepenta-6,7,9,11,13-ol, 1), was isolated from a rhizome extract of Kaempferia angustifolia Rosc. along with the known compounds crotepoxide, boesenboxide, zeylenol, 2′-hydroxy-4,4′,6′-trimethoxychalcone, (24S)-24-methyl-5α-lanosta-9(11),25-dien-3β-ol, β-sitosterol and β-sitosterol-3-O-β-D-glucopyranoside. The structures of all compounds were elucidated on the basis of mass spectroscopic and NMR data. Zeylenol (2), the major constituent of the plant, was derivatized into diacetate, triacetate and epoxide derivatives through standard organic reactions. The cytotoxic activity of compounds 1, 2 and the zeylenol derivatives was evaluated against the HL-60, MCF-7, HT-29 and HeLa cell lines.
Keywords: Kaempferia angustifolia; abietene diterpene; kaempfolienol; zeylenol; cytotoxic Kaempferia angustifolia; abietene diterpene; kaempfolienol; zeylenol; cytotoxic
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Tang, S.W.; Sukari, M.A.; Rahmani, M.; Lajis, N.H.; Ali, A.M. A New Abietene Diterpene and Other Constituents from Kaempferia angustifolia Rosc.. Molecules 2011, 16, 3018-3028.

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