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Molecules 2011, 16(4), 2796-2801; doi:10.3390/molecules16042796
Article

Cytotoxic Metabolites from the Soil-Derived Fungus Exophiala Pisciphila

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1,2 and 1,*
1 Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China 2 Graduate School of the Chinese Academy of Sciences, Beijing 100049, China
* Author to whom correspondence should be addressed.
Received: 28 January 2011 / Revised: 21 March 2011 / Accepted: 23 March 2011 / Published: 30 March 2011
(This article belongs to the collection Bioactive Compounds)
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Abstract

A new polyketide compound 1 and a new naturally occurring chromone derivative 2, along with two known indole alkaloids 34 were characterized from the ethyl acetate extract of a soil-derived fungal strain, Exophiala pisciphila PHF-9. The structures of compounds 14 were established by detailed spectroscopic analysis and comparison with literature data. The absolute configuration of 1 was determined by a modified Mosher’s method. Compound 1 exhibited moderate cytotoxicity against A-549, Hela, PANC-28 and BEL-7402 cell lines.
Keywords: polyketide; chromone; indole alkaloid; Mosher; Exophiala pisciphila polyketide; chromone; indole alkaloid; Mosher; Exophiala pisciphila
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Wang, C.-C.; Liu, H.-Z.; Liu, M.; Zhang, Y.-Y.; Li, T.-T.; Lin, X.-K. Cytotoxic Metabolites from the Soil-Derived Fungus Exophiala Pisciphila. Molecules 2011, 16, 2796-2801.

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