Next Article in Journal / Special Issue
Effects of Panax ginseng on Tumor Necrosis Factor-α-Mediated Inflammation: A Mini-Review
Previous Article in Journal / Special Issue
Antifeedant Triterpenoids from the Seeds and Bark of Lansium domesticum cv Kokossan (Meliaceae)
Molecules 2011, 16(4), 2796-2801; doi:10.3390/molecules16042796

Cytotoxic Metabolites from the Soil-Derived Fungus Exophiala Pisciphila

1,2 and 1,*
1 Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China 2 Graduate School of the Chinese Academy of Sciences, Beijing 100049, China
* Author to whom correspondence should be addressed.
Received: 28 January 2011 / Revised: 21 March 2011 / Accepted: 23 March 2011 / Published: 30 March 2011
(This article belongs to the collection Bioactive Compounds)
Download PDF [217 KB, uploaded 18 June 2014]


A new polyketide compound 1 and a new naturally occurring chromone derivative 2, along with two known indole alkaloids 34 were characterized from the ethyl acetate extract of a soil-derived fungal strain, Exophiala pisciphila PHF-9. The structures of compounds 14 were established by detailed spectroscopic analysis and comparison with literature data. The absolute configuration of 1 was determined by a modified Mosher’s method. Compound 1 exhibited moderate cytotoxicity against A-549, Hela, PANC-28 and BEL-7402 cell lines.
Keywords: polyketide; chromone; indole alkaloid; Mosher; Exophiala pisciphila polyketide; chromone; indole alkaloid; Mosher; Exophiala pisciphila
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Wang, C.-C.; Liu, H.-Z.; Liu, M.; Zhang, Y.-Y.; Li, T.-T.; Lin, X.-K. Cytotoxic Metabolites from the Soil-Derived Fungus Exophiala Pisciphila. Molecules 2011, 16, 2796-2801.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert