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Cytotoxic Metabolites from the Soil-Derived Fungus Exophiala Pisciphila
Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
Graduate School of the Chinese Academy of Sciences, Beijing 100049, China
* Author to whom correspondence should be addressed.
Received: 28 January 2011; in revised form: 21 March 2011 / Accepted: 23 March 2011 / Published: 30 March 2011
Abstract: A new polyketide compound 1 and a new naturally occurring chromone derivative 2, along with two known indole alkaloids 3–4 were characterized from the ethyl acetate extract of a soil-derived fungal strain, Exophiala pisciphila PHF-9. The structures of compounds 1–4 were established by detailed spectroscopic analysis and comparison with literature data. The absolute configuration of 1 was determined by a modified Mosher’s method. Compound 1 exhibited moderate cytotoxicity against A-549, Hela, PANC-28 and BEL-7402 cell lines.
Keywords: polyketide; chromone; indole alkaloid; Mosher; Exophiala pisciphila
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Wang, C.-C.; Liu, H.-Z.; Liu, M.; Zhang, Y.-Y.; Li, T.-T.; Lin, X.-K. Cytotoxic Metabolites from the Soil-Derived Fungus Exophiala Pisciphila. Molecules 2011, 16, 2796-2801.
Wang C-C, Liu H-Z, Liu M, Zhang Y-Y, Li T-T, Lin X-K. Cytotoxic Metabolites from the Soil-Derived Fungus Exophiala Pisciphila. Molecules. 2011; 16(4):2796-2801.
Wang, Cui-Cui; Liu, Hai-Zhou; Liu, Ming; Zhang, Yu-Yan; Li, Tian-Tian; Lin, Xiu-Kun. 2011. "Cytotoxic Metabolites from the Soil-Derived Fungus Exophiala Pisciphila." Molecules 16, no. 4: 2796-2801.