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Molecules 2011, 16(3), 2636-2645; doi:10.3390/molecules16032636

Immunosuppressive Activity of 8-Gingerol on Immune Responses in Mice

1,*  and 1,*
1 Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, Changchun, Jilin 130062, China 2 Laboratory of Nutrition and Function Food, Jilin University, Changchun, Jilin 130062, China These authors should be regarded as joint first author.
* Authors to whom correspondence should be addressed.
Received: 14 January 2011 / Revised: 12 March 2011 / Accepted: 16 March 2011 / Published: 22 March 2011
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8-Gingerol is one of the principal components of ginger, which is widely used in China and elsewhere as a food, spice and herb. It shows immunosuppressive activity on the immune responses to ovalbumin (OVA) in mice. In the present study, we found that 8-gingerol suppressed lipopolysaccharide (LPS) and concanavalin A (ConA)-stimulated splenocyte proliferation in vitro. In vivo, 8-gingerol not only significantly suppressed Con A-, LPS- and OVA-induced splenocyte proliferation (P < 0.05) but also decreased the percentage of CD19+ B cells and CD3+ T cell (P < 0.05) at high doses (50, 100 mg/kg). Moreover, OVA-specific IgG, IgG1 and IgG2b levels in OVA-immunized mice were reduced by 8-gingerol at doses of 50, 100 mg/kg. These results suggest that 8-gingerol could suppress humoral and cellular immune responses in mice. The mechanism might be related to direct inhibition of sensitized T and B lymphocytes.
Keywords: immunosuppression; 8-gingerol; humoral immune; cellular immune immunosuppression; 8-gingerol; humoral immune; cellular immune
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Lu, J.; Guan, S.; Shen, X.; Qian, W.; Huang, G.; Deng, X.; Xie, G. Immunosuppressive Activity of 8-Gingerol on Immune Responses in Mice. Molecules 2011, 16, 2636-2645.

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