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Molecules 2011, 16(3), 2636-2645; doi:10.3390/molecules16032636
Article

Immunosuppressive Activity of 8-Gingerol on Immune Responses in Mice

1,2,†
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1,†
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2
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1,*  and 1,*
1 Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, Changchun, Jilin 130062, China 2 Laboratory of Nutrition and Function Food, Jilin University, Changchun, Jilin 130062, China These authors should be regarded as joint first author.
* Authors to whom correspondence should be addressed.
Received: 14 January 2011 / Revised: 12 March 2011 / Accepted: 16 March 2011 / Published: 22 March 2011
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Abstract

8-Gingerol is one of the principal components of ginger, which is widely used in China and elsewhere as a food, spice and herb. It shows immunosuppressive activity on the immune responses to ovalbumin (OVA) in mice. In the present study, we found that 8-gingerol suppressed lipopolysaccharide (LPS) and concanavalin A (ConA)-stimulated splenocyte proliferation in vitro. In vivo, 8-gingerol not only significantly suppressed Con A-, LPS- and OVA-induced splenocyte proliferation (P < 0.05) but also decreased the percentage of CD19+ B cells and CD3+ T cell (P < 0.05) at high doses (50, 100 mg/kg). Moreover, OVA-specific IgG, IgG1 and IgG2b levels in OVA-immunized mice were reduced by 8-gingerol at doses of 50, 100 mg/kg. These results suggest that 8-gingerol could suppress humoral and cellular immune responses in mice. The mechanism might be related to direct inhibition of sensitized T and B lymphocytes.
Keywords: immunosuppression; 8-gingerol; humoral immune; cellular immune immunosuppression; 8-gingerol; humoral immune; cellular immune
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Lu, J.; Guan, S.; Shen, X.; Qian, W.; Huang, G.; Deng, X.; Xie, G. Immunosuppressive Activity of 8-Gingerol on Immune Responses in Mice. Molecules 2011, 16, 2636-2645.

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