Abstract: 8-Gingerol is one of the principal components of ginger, which is widely used in China and elsewhere as a food, spice and herb. It shows immunosuppressive activity on the immune responses to ovalbumin (OVA) in mice. In the present study, we found that 8-gingerol suppressed lipopolysaccharide (LPS) and concanavalin A (ConA)-stimulated splenocyte proliferation in vitro. In vivo, 8-gingerol not only signiﬁcantly suppressed Con A-, LPS- and OVA-induced splenocyte proliferation (P < 0.05) but also decreased the percentage of CD19+ B cells and CD3+ T cell (P < 0.05) at high doses (50, 100 mg/kg). Moreover, OVA-speciﬁc IgG, IgG1 and IgG2b levels in OVA-immunized mice were reduced by 8-gingerol at doses of 50, 100 mg/kg. These results suggest that 8-gingerol could suppress humoral and cellular immune responses in mice. The mechanism might be related to direct inhibition of sensitized T and B lymphocytes.
Keywords: immunosuppression; 8-gingerol; humoral immune; cellular immune
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Lu, J.; Guan, S.; Shen, X.; Qian, W.; Huang, G.; Deng, X.; Xie, G. Immunosuppressive Activity of 8-Gingerol on Immune Responses in Mice. Molecules 2011, 16, 2636-2645.
Lu J, Guan S, Shen X, Qian W, Huang G, Deng X, Xie G. Immunosuppressive Activity of 8-Gingerol on Immune Responses in Mice. Molecules. 2011; 16(3):2636-2645.
Lu, Jing; Guan, Shuang; Shen, Xue; Qian, Wenhui; Huang, Guoren; Deng, Xuming; Xie, Guanghong. 2011. "Immunosuppressive Activity of 8-Gingerol on Immune Responses in Mice." Molecules 16, no. 3: 2636-2645.