Next Article in Journal
Inter-Population Variability of Terpenoid Composition in Leaves of Pistacia lentiscus L. from Algeria: A Chemoecological Approach
Previous Article in Journal
Synthesis and In Vitro Antibacterial Activity of 7-(3-Amino-6,7-dihydro-2-methyl-2H-pyrazolo[4,3-c] Pyridin-5(4H)-yl)fluoroquinolone Derivatives
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2011, 16(3), 2636-2645; doi:10.3390/molecules16032636

Immunosuppressive Activity of 8-Gingerol on Immune Responses in Mice

Department of Veterinary Pharmacology, College of Animal Science and Veterinary Medicine, Jilin University, Changchun, Jilin 130062, China
Laboratory of Nutrition and Function Food, Jilin University, Changchun, Jilin 130062, China
These authors should be regarded as joint first author.
Authors to whom correspondence should be addressed.
Received: 14 January 2011 / Revised: 12 March 2011 / Accepted: 16 March 2011 / Published: 22 March 2011
Download PDF [209 KB, uploaded 18 June 2014]


8-Gingerol is one of the principal components of ginger, which is widely used in China and elsewhere as a food, spice and herb. It shows immunosuppressive activity on the immune responses to ovalbumin (OVA) in mice. In the present study, we found that 8-gingerol suppressed lipopolysaccharide (LPS) and concanavalin A (ConA)-stimulated splenocyte proliferation in vitro. In vivo, 8-gingerol not only significantly suppressed Con A-, LPS- and OVA-induced splenocyte proliferation (P < 0.05) but also decreased the percentage of CD19+ B cells and CD3+ T cell (P < 0.05) at high doses (50, 100 mg/kg). Moreover, OVA-specific IgG, IgG1 and IgG2b levels in OVA-immunized mice were reduced by 8-gingerol at doses of 50, 100 mg/kg. These results suggest that 8-gingerol could suppress humoral and cellular immune responses in mice. The mechanism might be related to direct inhibition of sensitized T and B lymphocytes.
Keywords: immunosuppression; 8-gingerol; humoral immune; cellular immune immunosuppression; 8-gingerol; humoral immune; cellular immune
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Lu, J.; Guan, S.; Shen, X.; Qian, W.; Huang, G.; Deng, X.; Xie, G. Immunosuppressive Activity of 8-Gingerol on Immune Responses in Mice. Molecules 2011, 16, 2636-2645.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top