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Protective Effect of Salidroside from Rhodiolae Radix on Diabetes-Induced Oxidative Stress in Mice
Key Laboratory of Metastable Materials Science and Technology, College of Materials Science and Engineering, Yanshan University, Qinghuangdao, 066004, China
Department of Bioengineering, Jilin Agricultural Science and Technology College, Jilin, 132101, China
Department of Endocrinology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China
College of Environment and Chemical Engineering, Yanshan University, Qinghuangdao, 066004, China
Department of Pharmacy, The First Affiliated Hospital of Henan College of Traditional Chinese Medicine, Zhengzhou, 450000, China
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 3 October 2011; in revised form: 18 November 2011 / Accepted: 22 November 2011 / Published: 1 December 2011
Abstract: It has been confirmed that diabetes mellitus (DM) carries increased oxidative stress. This study evaluated the effects of salidroside from Rhodiolae Radix on diabetes-induced oxidative stress in mice. After induction of diabetes, diabetic mice were administered daily doses of 50, 100 and 200 mg/kg salidroside for 28 days. Body weights, fasting blood glucose (FBG), serum insulin, TC (total cholesterol), TG (triglyceride), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were measured. Results showed that salidroside possessed hypoglycemic activity and protective effects against diabetes-induced oxidative stress, which could significantly reduce FBG, TC, TG and MDA levels, and at same time increase serum insulin levels, SOD, GPx and CAT activities. Therefore, salidroside should be considered as a candidate for future studies on diabetes.
Keywords: oxidative stress; diabetes mellitus; salidroside; hypoglycemic; mice
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MDPI and ACS Style
Li, F.; Tang, H.; Xiao, F.; Gong, J.; Peng, Y.; Meng, X. Protective Effect of Salidroside from Rhodiolae Radix on Diabetes-Induced Oxidative Stress in Mice. Molecules 2011, 16, 9912-9924.
Li F, Tang H, Xiao F, Gong J, Peng Y, Meng X. Protective Effect of Salidroside from Rhodiolae Radix on Diabetes-Induced Oxidative Stress in Mice. Molecules. 2011; 16(12):9912-9924.
Li, Fenglin; Tang, Hong; Xiao, Furen; Gong, Jingli; Peng, Yong; Meng, Xiangle. 2011. "Protective Effect of Salidroside from Rhodiolae Radix on Diabetes-Induced Oxidative Stress in Mice." Molecules 16, no. 12: 9912-9924.