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Effect of Ginkgo Leaf Parenteral Solution on Blood and Cochlea Antioxidant and Immunity Indexes in OM Rats
Department of Otolaryngology/Head and Neck Surgery, PLA General Hospital, Beijing 100853, China
* Author to whom correspondence should be addressed.
Received: 10 November 2011; in revised form: 27 November 2011 / Accepted: 7 December 2011 / Published: 15 December 2011
Abstract: Oxidative stress is involved in the development and progression of otitis media (OM). In this study, we investigated the effect of Ginkgo leaf parenteral solution on blood and cochlea antioxidant and immunity indexs in OM rats. In OM model rats, blood and cochlea malondialdehyde (MDA), nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8) and interleukin-10 (IL-10) levels were significantly increased, whereas antioxidant enzymes activities (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione reductase (GR)) were significantly decreased compared with normal rats. Treatment with Ginkgo leaf parenteral solution restored the altered parameters in a dose-dependent manner. We conclude that Ginkgo leaf parenteral solution confers protection against oxidative injuries in OM rats by increasing activities of antioxidants and immunity, suggesting a potential drug for the prevention and therapy of OM.
Keywords: otitis media; rat; ginkgo leaf parenteral solution; antioxidant; immunity
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MDPI and ACS Style
Zhao, J.; Su, Y.; Chen, A.; Yuan, H.; Liu, L.; Wu, W. Effect of Ginkgo Leaf Parenteral Solution on Blood and Cochlea Antioxidant and Immunity Indexes in OM Rats. Molecules 2011, 16, 10433-10442.
Zhao J, Su Y, Chen A, Yuan H, Liu L, Wu W. Effect of Ginkgo Leaf Parenteral Solution on Blood and Cochlea Antioxidant and Immunity Indexes in OM Rats. Molecules. 2011; 16(12):10433-10442.
Zhao, Jiandong; Su, Yu; Chen, Aiting; Yuan, Hu; Liu, Liangfa; Wu, Wenming. 2011. "Effect of Ginkgo Leaf Parenteral Solution on Blood and Cochlea Antioxidant and Immunity Indexes in OM Rats." Molecules 16, no. 12: 10433-10442.