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Effects of Lycium Barbarum Aqueous and Ethanol Extracts on High-Fat-Diet Induced Oxidative Stress in Rat Liver Tissue
Department of Hepatobiliary Oncology, Cancer Center, Sun Yat-sen University, 651 Dongfeng East Road, Guangzhou 510060, Guangdong Province, China
Department of Pharmocology, Guangzhou Institute for Drug Control, 23 Xizeng Road, Liwan District, Guangzhou 510160, Guangdong Province, China
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 26 October 2011; Accepted: 26 October 2011 / Published: 1 November 2011
Abstract: This study evaluated the protective effects of aqueous extract of Lycium barbarum (LBAE) and ethanol extract of Lycium barbarum (LBEE) on blood lipid levels, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) activities and liver tissue antioxidant enzyme activities in rats fed a high fat diet (HF). The rats were randomly divided into seven groups of ten rats each and fed a different diet for eight weeks as follows: One group (NC group) was fed a standard diet, one group was fed a high-fat diet (HF group), one group was fed a high-fat diet and orally fed with 20 mg/kg b.w. simvastatin (HF + simvastatin group), and the other group was fed the high fat diet and orally fed with 50 mg/kg b.w. or 100 mg/kg b.w. LBAE (HF + LBAE), or 50 mg/kg b.w. or 100 mg/kg b.w. LBEE (HF + LBEE), respectively. After eight weeks, the HF diet caused deleterious metabolic effects. Rats fed the HF diet alone showed increased hepatocellular enzyme activities in plasma, a significant decline in antioxidant enzyme activities, and elevated liver lipid peroxidation indices. LBAE and LBEE administration significantly reduced liver damage and oxidative changes, and brought back the antioxidants and lipids towards normal levels. These data suggest that these antioxidants protect against toxicity parameters in HF rats.
Keywords: Lycium barbarum; rat; antioxidant; AST; hepatoprotection
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Cui, B.; Liu, S.; Lin, X.; Wang, J.; Li, S.; Wang, Q.; Li, S. Effects of Lycium Barbarum Aqueous and Ethanol Extracts on High-Fat-Diet Induced Oxidative Stress in Rat Liver Tissue. Molecules 2011, 16, 9116-9128.
Cui B, Liu S, Lin X, Wang J, Li S, Wang Q, Li S. Effects of Lycium Barbarum Aqueous and Ethanol Extracts on High-Fat-Diet Induced Oxidative Stress in Rat Liver Tissue. Molecules. 2011; 16(11):9116-9128.
Cui, BoKang; Liu, Su; Lin, XiaoJun; Wang, Jun; Li, ShuHong; Wang, QiBo; Li, ShengPing. 2011. "Effects of Lycium Barbarum Aqueous and Ethanol Extracts on High-Fat-Diet Induced Oxidative Stress in Rat Liver Tissue." Molecules 16, no. 11: 9116-9128.