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Two New Xanthones from Calophyllum nodusum (Guttiferae)
Department of Chemistry, Universiti Putra Malaysia, 43400 UPM, Serdang, Malaysia
Department of Biology, Universiti Putra Malaysia, 43400 UPM, Serdang, Malaysia
* Author to whom correspondence should be addressed.
Received: 23 September 2011; Accepted: 17 October 2011 / Published: 25 October 2011
Abstract: The air-dried powdered stem bark of Calophyllum nodusum (Guttiferea) collected from Sandakan (Sabah, Malaysia), was extracted sequentially with hexane, chloroform and methanol. The solvents were removed by rotary evaporator to give dark viscous extracts. Detailed and repeated chromatographic separation of the extracts lead to isolation of two new xanthones, identified as nodusuxanthone (1a) and trapezifolixanthone A (2). Other common terpenoids such as betulinic acid, lupeol, stigmasterol and friedelin were also isolated from the extracts and identified. The structures of the compounds were established by detailed spectral analysis and comparison with previously reported data.
Keywords: Calophyllum nodusum; nodusuxanthone; trapezifolixanthone A; lupeol; stigmasterol
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Nasir, N.M.; Rahmani, M.; Shaari, K.; Ee, G.C.L.; Go, R.; Kassim, N.K.; Muhamad, S.N.K.; Iskandar, M.J. Two New Xanthones from Calophyllum nodusum (Guttiferae). Molecules 2011, 16, 8973-8980.
Nasir NM, Rahmani M, Shaari K, Ee GCL, Go R, Kassim NK, Muhamad SNK, Iskandar MJ. Two New Xanthones from Calophyllum nodusum (Guttiferae). Molecules. 2011; 16(11):8973-8980.
Nasir, Nadiah Mad; Rahmani, Mawardi; Shaari, Khozirah; Ee, Gwendoline Cheng Lian; Go, Rusea; Kassim, Nur Kartinee; Muhamad, Siti Noor Kamilah; Iskandar, Mohd Johadi. 2011. "Two New Xanthones from Calophyllum nodusum (Guttiferae)." Molecules 16, no. 11: 8973-8980.