Next Article in Journal
Previous Article in Journal
Molecules 2011, 16(10), 8601-8613; doi:10.3390/molecules16108601
Article

The Protective Effects of Silymarin against Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity in Rats

1
, 1,* , 2
, 1
, 1
 and 1
Received: 7 September 2011; in revised form: 5 October 2011 / Accepted: 10 October 2011 / Published: 12 October 2011
Download PDF [515 KB, uploaded 18 June 2014]
Abstract: Silymarin is a complex of five major compounds, and silibinin is the most biologically active component of the complex. The aim of this study was to investigate, evaluate and confirm the potential cardioprotective and hepatoprotective effects of administration of silymarin, rich in silibinin, at a dose of 60 mg/kg orally for a time-span of 12 days on doxorubicin induced toxicity in male Wistar rats. The in vivo model was used to explore whether silymarin could prevent damage of liver and heart tissue induced by doxorubicin administered every other day at dose of 1.66 mg/kg intraperitoneally for twelve days. In the study the change of body weight, ECG changes, biochemical parameters of oxidative stress, serum activity of alanine and aspartate transaminase, lactate dehydrogenase, creatine kinase and histological preparations of heart and liver samples of treated animals were examined. According to physiological, pharmacological, microscopic and biochemical results, we confirmed that at the examined dose, silymarin exhibits a protective influence on the heart and liver tissue against toxicity induced by doxorubicin.
Keywords: silymarin; silibinin; doxorubicin; cardiotoxicity; hepatotoxicity silymarin; silibinin; doxorubicin; cardiotoxicity; hepatotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Rašković, A.; Stilinović, N.; Kolarović, J.; Vasović, V.; Vukmirović, S.; Mikov, M. The Protective Effects of Silymarin against Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity in Rats. Molecules 2011, 16, 8601-8613.

AMA Style

Rašković A, Stilinović N, Kolarović J, Vasović V, Vukmirović S, Mikov M. The Protective Effects of Silymarin against Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity in Rats. Molecules. 2011; 16(10):8601-8613.

Chicago/Turabian Style

Rašković, Aleksandar; Stilinović, Nebojša; Kolarović, Jovanka; Vasović, Velibor; Vukmirović, Saša; Mikov, Momir. 2011. "The Protective Effects of Silymarin against Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity in Rats." Molecules 16, no. 10: 8601-8613.



Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert