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The Protective Effects of Silymarin against Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity in Rats
Department of Pharmacology, Toxicology and Clinical Pharmacology, School of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia
Department of Hematology and Oncology, Institute for Child and Youth Health Care of Vojvodina, Novi Sad, 21000 Novi Sad, Serbia
* Author to whom correspondence should be addressed.
Received: 7 September 2011; in revised form: 5 October 2011 / Accepted: 10 October 2011 / Published: 12 October 2011
Abstract: Silymarin is a complex of five major compounds, and silibinin is the most biologically active component of the complex. The aim of this study was to investigate, evaluate and confirm the potential cardioprotective and hepatoprotective effects of administration of silymarin, rich in silibinin, at a dose of 60 mg/kg orally for a time-span of 12 days on doxorubicin induced toxicity in male Wistar rats. The in vivo model was used to explore whether silymarin could prevent damage of liver and heart tissue induced by doxorubicin administered every other day at dose of 1.66 mg/kg intraperitoneally for twelve days. In the study the change of body weight, ECG changes, biochemical parameters of oxidative stress, serum activity of alanine and aspartate transaminase, lactate dehydrogenase, creatine kinase and histological preparations of heart and liver samples of treated animals were examined. According to physiological, pharmacological, microscopic and biochemical results, we confirmed that at the examined dose, silymarin exhibits a protective influence on the heart and liver tissue against toxicity induced by doxorubicin.
Keywords: silymarin; silibinin; doxorubicin; cardiotoxicity; hepatotoxicity
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Rašković, A.; Stilinović, N.; Kolarović, J.; Vasović, V.; Vukmirović, S.; Mikov, M. The Protective Effects of Silymarin against Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity in Rats. Molecules 2011, 16, 8601-8613.
Rašković A, Stilinović N, Kolarović J, Vasović V, Vukmirović S, Mikov M. The Protective Effects of Silymarin against Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity in Rats. Molecules. 2011; 16(10):8601-8613.
Rašković, Aleksandar; Stilinović, Nebojša; Kolarović, Jovanka; Vasović, Velibor; Vukmirović, Saša; Mikov, Momir. 2011. "The Protective Effects of Silymarin against Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity in Rats." Molecules 16, no. 10: 8601-8613.