Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives
AbstractNew diterpenylquinones, combining a diterpene diacid and a naphthoquinone, were prepared from junicedric acid and lapachol. The new derivatives were assessed as gastroprotective agents by the HCl-EtOH-induced gastric lesions model in mice as well as for basal cytotoxicity on the following human cell lines: Normal lung fibroblasts (MRC-5), gastric epithelial adenocarcinoma (AGS), and hepatocellular carcinoma (Hep G2). Several of the new compounds were significantly active as antiulcer agents and showed selective cytotoxicity against AGS cells.
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Pertino, M.W.; Theoduloz, C.; Palenzuela, J.A.; Afonso, M.M.; Yesilada, E.; Monsalve, F.; González, P.; Droguett, D.; Schmeda-Hirschmann, G. Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives. Molecules 2011, 16, 8614-8628.
Pertino MW, Theoduloz C, Palenzuela JA, Afonso MM, Yesilada E, Monsalve F, González P, Droguett D, Schmeda-Hirschmann G. Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives. Molecules. 2011; 16(10):8614-8628.Chicago/Turabian Style
Pertino, Mariano Walter; Theoduloz, Cristina; Palenzuela, Jose Antonio; Afonso, Maria del Mar; Yesilada, Erdem; Monsalve, Francisco; González, Paulo; Droguett, Daniel; Schmeda-Hirschmann, Guillermo. 2011. "Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives." Molecules 16, no. 10: 8614-8628.