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Molecules 2011, 16(10), 8614-8628; doi:10.3390/molecules16108614
Article

Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives

1, 2, 3, 3, 4, 2, 2, 2 and 1,*
Received: 13 September 2011; in revised form: 29 September 2011 / Accepted: 30 September 2011 / Published: 13 October 2011
(This article belongs to the Section Medicinal Chemistry)
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Abstract: New diterpenylquinones, combining a diterpene diacid and a naphthoquinone, were prepared from junicedric acid and lapachol. The new derivatives were assessed as gastroprotective agents by the HCl-EtOH-induced gastric lesions model in mice as well as for basal cytotoxicity on the following human cell lines: Normal lung fibroblasts (MRC-5), gastric epithelial adenocarcinoma (AGS), and hepatocellular carcinoma (Hep G2). Several of the new compounds were significantly active as antiulcer agents and showed selective cytotoxicity against AGS cells.
Keywords: labdane diterpenes; lapachol derivatives; diterpenylnaphthoquinones; gastroprotection; basal cytotoxicity labdane diterpenes; lapachol derivatives; diterpenylnaphthoquinones; gastroprotection; basal cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Pertino, M.W.; Theoduloz, C.; Palenzuela, J.A.; Afonso, M.M.; Yesilada, E.; Monsalve, F.; González, P.; Droguett, D.; Schmeda-Hirschmann, G. Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives. Molecules 2011, 16, 8614-8628.

AMA Style

Pertino MW, Theoduloz C, Palenzuela JA, Afonso MM, Yesilada E, Monsalve F, González P, Droguett D, Schmeda-Hirschmann G. Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives. Molecules. 2011; 16(10):8614-8628.

Chicago/Turabian Style

Pertino, Mariano Walter; Theoduloz, Cristina; Palenzuela, Jose Antonio; Afonso, Maria del Mar; Yesilada, Erdem; Monsalve, Francisco; González, Paulo; Droguett, Daniel; Schmeda-Hirschmann, Guillermo. 2011. "Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives." Molecules 16, no. 10: 8614-8628.


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