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Molecules 2011, 16(1), 933-950; doi:10.3390/molecules16010933

Preparation of Polyester-Based Metal-Cross Linked Polymeric Composites as Novel Materials Resistant to Bacterial Adhesion and Biofilm Formation

1
Department of Pharmaceutical Sciences and Pharmaceutics, Applied Science University, Amman, Jordan
2
Department of Chemistry, Faculty of Sciences, University of Jordan, Amman, Jordan
3
Department of Biology, Faculty of Sciences, University of Jordan, Amman, Jordan
4
Drug Discovery Unit, Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman, Jordan
*
Author to whom correspondence should be addressed.
Received: 27 November 2010 / Revised: 25 December 2010 / Accepted: 17 January 2011 / Published: 21 January 2011
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Abstract

Bacterial biofilms constitute an extremely resistant form of bacterial colonization with dire health and economical implications. Towards achieving polymeric composites capable of resisting bacterial adhesion and biofilm formation, we prepared five 2,6-pyridinedicarboxylate-based polyesters employing five different diol monomers. The resulting polyesters were complexed with copper (II) or silver (I). The new polymers were characterized by proton and carbon nuclear magnetic resonance spectroscopy, inherent viscosity, infrared spectroscopy, differential scanning calorimetry and thermogravimetric analysis. The corresponding metal complexes were characterized by differential scanning calorimery and infrared spectroscopy. The amounts of complexed copper and silver were determined by atomic absorption spectrophotometry. Finally, the resulting composites were tested for their antibacterial potential and were found to effectively resist bacterial attachment and growth.
Keywords: bacterial biofilms; 2,6-pyridinedicarboxylate; copper complexes; silver complexes; polyesters bacterial biofilms; 2,6-pyridinedicarboxylate; copper complexes; silver complexes; polyesters
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Saleh, S.; Sweileh, B.; Taha, S.O.; Mahmoud, R.; Taha, M.O. Preparation of Polyester-Based Metal-Cross Linked Polymeric Composites as Novel Materials Resistant to Bacterial Adhesion and Biofilm Formation. Molecules 2011, 16, 933-950.

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