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Molecules 2011, 16(1), 466-476; doi:10.3390/molecules16010466

Feeding Deterrents against Two Grain Storage Insects from Euphorbia fischeriana

1, 2,* , 3, 2, 3, 3, 3,*  and 1
1 Analytical and Testing Center, Beijing Normal University, Beijing 100875, China 2 Department of Entomology, China Agricultural University, Haidian District, Beijing 100094, China 3 Protection and Utilization of Traditional Chinese Medicine of Beijing Area Major Laboratory, Beijing Normal University, Haidian District, Beijing 100875, China
* Authors to whom correspondence should be addressed.
Received: 17 November 2010 / Revised: 5 January 2011 / Accepted: 7 January 2011 / Published: 10 January 2011
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The screening of several Chinese medicinal herbs for insecticidal principles showed that Euphorbia fischeriana roots possessed significant feeding deterrent activity against two stored-product insects (Tribolium castaneum and Sitophilus zeamais). From ethanol extract, four feeding deterrents were isolated by bioassay-guided fractionation. The compounds were identified as jolkinolide B, 12-deoxyphorbol 13-(9Z)-octadecenoate 20-acetate, 17-hydroxyjolkinolide A and B on the basis of their phytochemical and spectral data. Jolkinolide B and 17-hydroxyjolkinolide B possessed strong feeding deterrent activities against S. zeamais (EC50 = 342.1 and 543.9 ppm, respectively) and T. castaneum adults (EC50 = 361.4 and 551.5 ppm, respectively). 17-Hydroxyjolkinolide A and 12-deoxyphorbol 13-(9Z)-octadecenoate 20-acetate A also exhibited feeding deterrent activity against the two grain storage insects with EC50 values of 631.9 and 884.3 ppm for S. zeamais and 656.5 and 1058.4 ppm for T. castaneum adults.
Keywords: feeding deterrents; Euphorbia fischeriana; Tribolium castaneum; Sitophilus zeamais feeding deterrents; Euphorbia fischeriana; Tribolium castaneum; Sitophilus zeamais
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Geng, Z.F.; Liu, Z.L.; Wang, C.F.; Liu, Q.Z.; Shen, S.M.; Liu, Z.M.; Du, S.S.; Deng, Z.W. Feeding Deterrents against Two Grain Storage Insects from Euphorbia fischeriana. Molecules 2011, 16, 466-476.

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