Molecules 2011, 16(1), 291-297; doi:10.3390/molecules16010291
Communication

Relationship between Oversulfation and Conformation of Low and High Molecular Weight Fucoidans and Evaluation of Their in Vitro Anticancer Activity

Received: 30 November 2010; in revised form: 24 December 2010 / Accepted: 28 December 2010 / Published: 30 December 2010
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Abstract: Low and high molecular weight fucoidans (F5-30K and F>30K) were chemically modified through the addition of sulfate groups, and the effect of oversulfation on the in vitro anticancer activity was investigated. After the addition of sulfate groups, a considerable increase of 35.5 to 56.8% was observed in the sulfate content of the F5-30K fraction, while the sulfate content of the F>30K fraction increased to a lesser extent (from 31.7 to 41.2%). Significant differences in anticancer activity were observed between the oversulfated F5–30K and F>30K fractions, with activities of 37.3–68.0% and 20.6–35.8%, respectively. This variation in the anticancer activity of oversulfated fucoidan derivatives was likely due to differences in their sulfate content. The results suggest that the molecular conformation of these molecules is closely related to the extent of sulfation in the fucan backbones and that the sulfates are preferably substituted when the fucoidan polymers are in a loose molecular conformation.
Keywords: fucoidans; oversulfation; molecular conformation; anticancer activity; Undaria pinnatifida
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MDPI and ACS Style

Cho, M.L.; Lee, B.-Y.; You, S.G. Relationship between Oversulfation and Conformation of Low and High Molecular Weight Fucoidans and Evaluation of Their in Vitro Anticancer Activity. Molecules 2011, 16, 291-297.

AMA Style

Cho ML, Lee B-Y, You SG. Relationship between Oversulfation and Conformation of Low and High Molecular Weight Fucoidans and Evaluation of Their in Vitro Anticancer Activity. Molecules. 2011; 16(1):291-297.

Chicago/Turabian Style

Cho, Myoung Lae; Lee, Boo-Yong; You, Sang Guan. 2011. "Relationship between Oversulfation and Conformation of Low and High Molecular Weight Fucoidans and Evaluation of Their in Vitro Anticancer Activity." Molecules 16, no. 1: 291-297.

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