Molecules 2011, 16(1), 298-306; doi:10.3390/molecules16010298
Article

A Route to Dicyanomethylene Pyridines and Substituted Benzonitriles Utilizing Malononitrile Dimer as a Precursor

1,* email, 1, 1 and 2
Received: 12 October 2010; in revised form: 20 December 2010 / Accepted: 22 December 2010 / Published: 4 January 2011
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The conditions of the reaction of malononitrile dimer with enaminones and arylidenemalononitrile could be adapted to yield either pyridines or benzene derivatives. A new synthesis of pyrido[1,2-a]pyrimidines from the reaction of malononitrile dimer 1 and 2-phenyl-3-piperidin-1-yl-acrylonitrile (11) is described. Compound 1 condensed with DMFDMA to yield an enaminonitrile that reacted with hydrazine hydrate to yield N',4,6-triamino-2H-pyrazolo[3,4-b]pyridine-5-carboxamidine (17).
Keywords: malononitrile dimer; arlymethylenemalononitrile; benzylidenemalononitrile; pyrazolopyridine
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MDPI and ACS Style

Helmy, N.M.; El-Baih, F.E.M.; Al-Alshaikh, M.A.; Moustafa, M.S. A Route to Dicyanomethylene Pyridines and Substituted Benzonitriles Utilizing Malononitrile Dimer as a Precursor. Molecules 2011, 16, 298-306.

AMA Style

Helmy NM, El-Baih FEM, Al-Alshaikh MA, Moustafa MS. A Route to Dicyanomethylene Pyridines and Substituted Benzonitriles Utilizing Malononitrile Dimer as a Precursor. Molecules. 2011; 16(1):298-306.

Chicago/Turabian Style

Helmy, Noha M.; El-Baih, Fatma E. M.; Al-Alshaikh, Monirah A.; Moustafa, Moustafa S. 2011. "A Route to Dicyanomethylene Pyridines and Substituted Benzonitriles Utilizing Malononitrile Dimer as a Precursor." Molecules 16, no. 1: 298-306.

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