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Molecules 2011, 16(1), 298-306; doi:10.3390/molecules16010298
Article

A Route to Dicyanomethylene Pyridines and Substituted Benzonitriles Utilizing Malononitrile Dimer as a Precursor

1,* , 1, 1 and 2
Received: 12 October 2010 / Revised: 20 December 2010 / Accepted: 22 December 2010 / Published: 4 January 2011
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Abstract

The conditions of the reaction of malononitrile dimer with enaminones and arylidenemalononitrile could be adapted to yield either pyridines or benzene derivatives. A new synthesis of pyrido[1,2-a]pyrimidines from the reaction of malononitrile dimer 1 and 2-phenyl-3-piperidin-1-yl-acrylonitrile (11) is described. Compound 1 condensed with DMFDMA to yield an enaminonitrile that reacted with hydrazine hydrate to yield N',4,6-triamino-2H-pyrazolo[3,4-b]pyridine-5-carboxamidine (17).
Keywords: malononitrile dimer; arlymethylenemalononitrile; benzylidenemalononitrile; pyrazolopyridine malononitrile dimer; arlymethylenemalononitrile; benzylidenemalononitrile; pyrazolopyridine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Helmy, N.M.; El-Baih, F.E.M.; Al-Alshaikh, M.A.; Moustafa, M.S. A Route to Dicyanomethylene Pyridines and Substituted Benzonitriles Utilizing Malononitrile Dimer as a Precursor. Molecules 2011, 16, 298-306.

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