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Molecules 2011, 16(1), 298-306; doi:10.3390/molecules16010298
Article

A Route to Dicyanomethylene Pyridines and Substituted Benzonitriles Utilizing Malononitrile Dimer as a Precursor

1,* , 1, 1 and 2
1 Women Students-Medical Studies & Sciences Sections, Chemistry Department, College of Science, King Saud University, Riyadh, KSA, P.O. Box 22452, Riyadh 11495, Saudi Arabia 2 Department of Chemistry, Faculty of Science, University of Kuwait, Safat 13060, Kuwait
* Author to whom correspondence should be addressed.
Received: 12 October 2010 / Revised: 20 December 2010 / Accepted: 22 December 2010 / Published: 4 January 2011
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Abstract

The conditions of the reaction of malononitrile dimer with enaminones and arylidenemalononitrile could be adapted to yield either pyridines or benzene derivatives. A new synthesis of pyrido[1,2-a]pyrimidines from the reaction of malononitrile dimer 1 and 2-phenyl-3-piperidin-1-yl-acrylonitrile (11) is described. Compound 1 condensed with DMFDMA to yield an enaminonitrile that reacted with hydrazine hydrate to yield N',4,6-triamino-2H-pyrazolo[3,4-b]pyridine-5-carboxamidine (17).
Keywords: malononitrile dimer; arlymethylenemalononitrile; benzylidenemalononitrile; pyrazolopyridine malononitrile dimer; arlymethylenemalononitrile; benzylidenemalononitrile; pyrazolopyridine
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Helmy, N.M.; El-Baih, F.E.M.; Al-Alshaikh, M.A.; Moustafa, M.S. A Route to Dicyanomethylene Pyridines and Substituted Benzonitriles Utilizing Malononitrile Dimer as a Precursor. Molecules 2011, 16, 298-306.

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