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Anti-Fatigue Activity of Extracts of Stem Bark from Acanthopanax senticosus
Physical Education College, Zhengzhou University, Zhengzhou 450044, China
Henan Ball Games Management Center, Zhengzhou 450044, China
Henan Research Institute of Sport Science, Zhengzhou, 450044, China
* Author to whom correspondence should be addressed.
Received: 24 November 2010; in revised form: 20 December 2010 / Accepted: 22 December 2010 / Published: 24 December 2010
Abstract: In the present study, we investigated the anti-fatigue activity in male Kunming mice of extracts of stem bark from Acanthopanax senticosus (ASSE) using a forced swimming test. Mice were divided into four groups (three ASSE administered groups and the control group). The control group were gavaged with distilled water and ASSE administered groups were gavaged with ASSE (100, 200 and 400 mg/kg). After four weeks, a forced swimming test was performed and the biochemical parameters related to fatigue were examined. The results suggested that ASSE could extend the swimming time to exhaustion of the mice, as well as increase the tissue glycogen contents, while decreasing the blood lactate and serum urea nitrogen contents. This indicated that ASSE had anti-fatigue activity and could elevate the exercise tolerance.
Keywords: anti-fatigue; Acanthopanax senticosus; forced swimming test; mice
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Zhang, X.-L.; Ren, F.; Huang, W.; Ding, R.-T.; Zhou, Q.-S.; Liu, X.-W. Anti-Fatigue Activity of Extracts of Stem Bark from Acanthopanax senticosus. Molecules 2011, 16, 28-37.
Zhang X-L, Ren F, Huang W, Ding R-T, Zhou Q-S, Liu X-W. Anti-Fatigue Activity of Extracts of Stem Bark from Acanthopanax senticosus. Molecules. 2011; 16(1):28-37.
Zhang, Xue-Ling; Ren, Feng; Huang, Wei; Ding, Ren-Tao; Zhou, Qiu-Sheng; Liu, Xin-Wei. 2011. "Anti-Fatigue Activity of Extracts of Stem Bark from Acanthopanax senticosus." Molecules 16, no. 1: 28-37.