Molecules 2011, 16(1), 16-27; doi:10.3390/molecules16010016
Article

Novel Synthesis of Hydrazide-Hydrazone Derivatives and Their Utilization in the Synthesis of Coumarin, Pyridine, Thiazole and Thiophene Derivatives with Antitumor Activity

Rafat M. Mohareb 1,2,* email, Daisy H. Fleita 3  and Ola K. Sakka 3
1 Department of Organic Chemistry, Faculty of Pharmacy, October University for Modern Sciences and Arts, October City, A.R., Egypt 2 Department of Chemistry, Faculty of Science, Cairo University, Giza, A.R., Egypt 3 Department of Chemistry, Faculty of Science, American University in Cairo, 5th Settlement, A.R., Egypt
* Author to whom correspondence should be addressed.
Received: 11 November 2010; in revised form: 5 December 2010 / Accepted: 8 December 2010 / Published: 23 December 2010
(This article belongs to the Section Organic Synthesis)
PDF Full-text Download PDF Full-Text [135 KB, uploaded 23 December 2010 17:09 CET]
Abstract: The reaction of cyanoacetyl hydrazine (1) with 3-acetylpyridine (2) gave the hydrazide-hydrazone derivative 3. The latter compound undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) was performed. Most of the synthesized compounds showed high inhibitory effects.
Keywords: hydrazide-hydrazone; 3-acetylpyridine; thiophene; coumarin; antitumor activity

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Mohareb, R.M.; Fleita, D.H.; Sakka, O.K. Novel Synthesis of Hydrazide-Hydrazone Derivatives and Their Utilization in the Synthesis of Coumarin, Pyridine, Thiazole and Thiophene Derivatives with Antitumor Activity. Molecules 2011, 16, 16-27.

AMA Style

Mohareb RM, Fleita DH, Sakka OK. Novel Synthesis of Hydrazide-Hydrazone Derivatives and Their Utilization in the Synthesis of Coumarin, Pyridine, Thiazole and Thiophene Derivatives with Antitumor Activity. Molecules. 2011; 16(1):16-27.

Chicago/Turabian Style

Mohareb, Rafat M.; Fleita, Daisy H.; Sakka, Ola K. 2011. "Novel Synthesis of Hydrazide-Hydrazone Derivatives and Their Utilization in the Synthesis of Coumarin, Pyridine, Thiazole and Thiophene Derivatives with Antitumor Activity." Molecules 16, no. 1: 16-27.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert