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Molecules 2011, 16(1), 16-27; doi:10.3390/molecules16010016

Novel Synthesis of Hydrazide-Hydrazone Derivatives and Their Utilization in the Synthesis of Coumarin, Pyridine, Thiazole and Thiophene Derivatives with Antitumor Activity

1
Department of Organic Chemistry, Faculty of Pharmacy, October University for Modern Sciences and Arts, October City, A.R., Egypt
2
Department of Chemistry, Faculty of Science, Cairo University, Giza, A.R., Egypt
3
Department of Chemistry, Faculty of Science, American University in Cairo, 5th Settlement, A.R., Egypt
*
Author to whom correspondence should be addressed.
Received: 11 November 2010 / Revised: 5 December 2010 / Accepted: 8 December 2010 / Published: 23 December 2010
(This article belongs to the Section Organic Synthesis)
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Abstract

The reaction of cyanoacetyl hydrazine (1) with 3-acetylpyridine (2) gave the hydrazide-hydrazone derivative 3. The latter compound undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) was performed. Most of the synthesized compounds showed high inhibitory effects.
Keywords: hydrazide-hydrazone; 3-acetylpyridine; thiophene; coumarin; antitumor activity hydrazide-hydrazone; 3-acetylpyridine; thiophene; coumarin; antitumor activity
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Mohareb, R.M.; Fleita, D.H.; Sakka, O.K. Novel Synthesis of Hydrazide-Hydrazone Derivatives and Their Utilization in the Synthesis of Coumarin, Pyridine, Thiazole and Thiophene Derivatives with Antitumor Activity. Molecules 2011, 16, 16-27.

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