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Molecules 2011, 16(1), 16-27; doi:10.3390/molecules16010016
Article

Novel Synthesis of Hydrazide-Hydrazone Derivatives and Their Utilization in the Synthesis of Coumarin, Pyridine, Thiazole and Thiophene Derivatives with Antitumor Activity

1,2,* , 3 and 3
1 Department of Organic Chemistry, Faculty of Pharmacy, October University for Modern Sciences and Arts, October City, A.R., Egypt 2 Department of Chemistry, Faculty of Science, Cairo University, Giza, A.R., Egypt 3 Department of Chemistry, Faculty of Science, American University in Cairo, 5th Settlement, A.R., Egypt
* Author to whom correspondence should be addressed.
Received: 11 November 2010 / Revised: 5 December 2010 / Accepted: 8 December 2010 / Published: 23 December 2010
(This article belongs to the Section Organic Synthesis)
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Abstract

The reaction of cyanoacetyl hydrazine (1) with 3-acetylpyridine (2) gave the hydrazide-hydrazone derivative 3. The latter compound undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) was performed. Most of the synthesized compounds showed high inhibitory effects.
Keywords: hydrazide-hydrazone; 3-acetylpyridine; thiophene; coumarin; antitumor activity hydrazide-hydrazone; 3-acetylpyridine; thiophene; coumarin; antitumor activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mohareb, R.M.; Fleita, D.H.; Sakka, O.K. Novel Synthesis of Hydrazide-Hydrazone Derivatives and Their Utilization in the Synthesis of Coumarin, Pyridine, Thiazole and Thiophene Derivatives with Antitumor Activity. Molecules 2011, 16, 16-27.

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