Next Article in Journal
Anti-Fatigue Activity of Extracts of Stem Bark from Acanthopanax senticosus
Previous Article in Journal
Triterpenoid Contents and Anti-Inflammatory Properties of the Methanol Extracts of Ligustrum Species Leaves
Molecules 2011, 16(1), 16-27; doi:10.3390/molecules16010016
Article

Novel Synthesis of Hydrazide-Hydrazone Derivatives and Their Utilization in the Synthesis of Coumarin, Pyridine, Thiazole and Thiophene Derivatives with Antitumor Activity

1,2,* , 3 and 3
1 Department of Organic Chemistry, Faculty of Pharmacy, October University for Modern Sciences and Arts, October City, A.R., Egypt 2 Department of Chemistry, Faculty of Science, Cairo University, Giza, A.R., Egypt 3 Department of Chemistry, Faculty of Science, American University in Cairo, 5th Settlement, A.R., Egypt
* Author to whom correspondence should be addressed.
Received: 11 November 2010 / Revised: 5 December 2010 / Accepted: 8 December 2010 / Published: 23 December 2010
(This article belongs to the Section Organic Synthesis)
Download PDF [135 KB, uploaded 18 June 2014]   |  

Abstract

The reaction of cyanoacetyl hydrazine (1) with 3-acetylpyridine (2) gave the hydrazide-hydrazone derivative 3. The latter compound undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) was performed. Most of the synthesized compounds showed high inhibitory effects.
Keywords: hydrazide-hydrazone; 3-acetylpyridine; thiophene; coumarin; antitumor activity hydrazide-hydrazone; 3-acetylpyridine; thiophene; coumarin; antitumor activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Mohareb, R.M.; Fleita, D.H.; Sakka, O.K. Novel Synthesis of Hydrazide-Hydrazone Derivatives and Their Utilization in the Synthesis of Coumarin, Pyridine, Thiazole and Thiophene Derivatives with Antitumor Activity. Molecules 2011, 16, 16-27.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert