Next Article in Journal
Previous Article in Journal
Molecules 2011, 16(1), 16-27; doi:10.3390/molecules16010016
Article

Novel Synthesis of Hydrazide-Hydrazone Derivatives and Their Utilization in the Synthesis of Coumarin, Pyridine, Thiazole and Thiophene Derivatives with Antitumor Activity

1,2,* , 3 and 3
Received: 11 November 2010; in revised form: 5 December 2010 / Accepted: 8 December 2010 / Published: 23 December 2010
(This article belongs to the Section Organic Synthesis)
Download PDF [135 KB, uploaded 18 June 2014]
Abstract: The reaction of cyanoacetyl hydrazine (1) with 3-acetylpyridine (2) gave the hydrazide-hydrazone derivative 3. The latter compound undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) was performed. Most of the synthesized compounds showed high inhibitory effects.
Keywords: hydrazide-hydrazone; 3-acetylpyridine; thiophene; coumarin; antitumor activity hydrazide-hydrazone; 3-acetylpyridine; thiophene; coumarin; antitumor activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Mohareb, R.M.; Fleita, D.H.; Sakka, O.K. Novel Synthesis of Hydrazide-Hydrazone Derivatives and Their Utilization in the Synthesis of Coumarin, Pyridine, Thiazole and Thiophene Derivatives with Antitumor Activity. Molecules 2011, 16, 16-27.

AMA Style

Mohareb RM, Fleita DH, Sakka OK. Novel Synthesis of Hydrazide-Hydrazone Derivatives and Their Utilization in the Synthesis of Coumarin, Pyridine, Thiazole and Thiophene Derivatives with Antitumor Activity. Molecules. 2011; 16(1):16-27.

Chicago/Turabian Style

Mohareb, Rafat M.; Fleita, Daisy H.; Sakka, Ola K. 2011. "Novel Synthesis of Hydrazide-Hydrazone Derivatives and Their Utilization in the Synthesis of Coumarin, Pyridine, Thiazole and Thiophene Derivatives with Antitumor Activity." Molecules 16, no. 1: 16-27.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert