Molecules 2010, 15(9), 6485-6492; doi:10.3390/molecules15096485

Synthesis and Antifungal Activity of Carabrone Derivatives

1,* email, 1, 1, 1, 1,2,* email and 1
Received: 6 July 2010; in revised form: 11 August 2010 / Accepted: 23 August 2010 / Published: 16 September 2010
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Nine derivatives 6-14 of carabrone (1) were synthesized and tested in vitro against Colletotrichum lagenarium Ell et Halst using the spore germination method. Among all of the derivatives, compounds 6-8 and 12 showed more potent antifungal activity than 1. Structure-activity relationships (SAR) demonstrated that the γ-lactone was necessary for the antifungal activity of 1, and the substituents on the C-4 position of 1 could significantly affect the antifungal activity.
Keywords: carabrone; structural modification; synthesis; antifungal activity
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MDPI and ACS Style

Feng, J.-T.; Ma, Z.-Q.; Li, J.-H.; He, J.; Xu, H.; Zhang, X. Synthesis and Antifungal Activity of Carabrone Derivatives. Molecules 2010, 15, 6485-6492.

AMA Style

Feng J-T, Ma Z-Q, Li J-H, He J, Xu H, Zhang X. Synthesis and Antifungal Activity of Carabrone Derivatives. Molecules. 2010; 15(9):6485-6492.

Chicago/Turabian Style

Feng, Jun-Tao; Ma, Zhi-Qing; Li, Jiang-Hua; He, Jun; Xu, Hui; Zhang, Xing. 2010. "Synthesis and Antifungal Activity of Carabrone Derivatives." Molecules 15, no. 9: 6485-6492.

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