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Molecules 2010, 15(9), 6485-6492; doi:10.3390/molecules15096485
Communication

Synthesis and Antifungal Activity of Carabrone Derivatives

1,* , 1, 1, 1, 1,2,*  and 1
1 Research and Development Center of Biorational Pesticide, College of Plant Protection, Northwest A&F University, Yangling 712100, China 2 Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University,Yangling 712100, China
* Authors to whom correspondence should be addressed.
Received: 6 July 2010 / Revised: 11 August 2010 / Accepted: 23 August 2010 / Published: 16 September 2010
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Abstract

Nine derivatives 6-14 of carabrone (1) were synthesized and tested in vitro against Colletotrichum lagenarium Ell et Halst using the spore germination method. Among all of the derivatives, compounds 6-8 and 12 showed more potent antifungal activity than 1. Structure-activity relationships (SAR) demonstrated that the γ-lactone was necessary for the antifungal activity of 1, and the substituents on the C-4 position of 1 could significantly affect the antifungal activity.
Keywords: carabrone; structural modification; synthesis; antifungal activity carabrone; structural modification; synthesis; antifungal activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Feng, J.-T.; Ma, Z.-Q.; Li, J.-H.; He, J.; Xu, H.; Zhang, X. Synthesis and Antifungal Activity of Carabrone Derivatives. Molecules 2010, 15, 6485-6492.

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