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Molecules 2010, 15(9), 6485-6492; doi:10.3390/molecules15096485

Synthesis and Antifungal Activity of Carabrone Derivatives

1,* , 1, 1, 1, 1,2,*  and 1
1 Research and Development Center of Biorational Pesticide, College of Plant Protection, Northwest A&F University, Yangling 712100, China 2 Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University,Yangling 712100, China
* Authors to whom correspondence should be addressed.
Received: 6 July 2010 / Revised: 11 August 2010 / Accepted: 23 August 2010 / Published: 16 September 2010
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Nine derivatives 6-14 of carabrone (1) were synthesized and tested in vitro against Colletotrichum lagenarium Ell et Halst using the spore germination method. Among all of the derivatives, compounds 6-8 and 12 showed more potent antifungal activity than 1. Structure-activity relationships (SAR) demonstrated that the γ-lactone was necessary for the antifungal activity of 1, and the substituents on the C-4 position of 1 could significantly affect the antifungal activity.
Keywords: carabrone; structural modification; synthesis; antifungal activity carabrone; structural modification; synthesis; antifungal activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Feng, J.-T.; Ma, Z.-Q.; Li, J.-H.; He, J.; Xu, H.; Zhang, X. Synthesis and Antifungal Activity of Carabrone Derivatives. Molecules 2010, 15, 6485-6492.

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