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Synthesis and Antifungal Activity of Carabrone Derivatives
AbstractNine derivatives 6-14 of carabrone (1) were synthesized and tested in vitro against Colletotrichum lagenarium Ell et Halst using the spore germination method. Among all of the derivatives, compounds 6-8 and 12 showed more potent antifungal activity than 1. Structure-activity relationships (SAR) demonstrated that the γ-lactone was necessary for the antifungal activity of 1, and the substituents on the C-4 position of 1 could significantly affect the antifungal activity.
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Feng, J.-T.; Ma, Z.-Q.; Li, J.-H.; He, J.; Xu, H.; Zhang, X. Synthesis and Antifungal Activity of Carabrone Derivatives. Molecules 2010, 15, 6485-6492.View more citation formats
Feng J-T, Ma Z-Q, Li J-H, He J, Xu H, Zhang X. Synthesis and Antifungal Activity of Carabrone Derivatives. Molecules. 2010; 15(9):6485-6492.Chicago/Turabian Style
Feng, Jun-Tao; Ma, Zhi-Qing; Li, Jiang-Hua; He, Jun; Xu, Hui; Zhang, Xing. 2010. "Synthesis and Antifungal Activity of Carabrone Derivatives." Molecules 15, no. 9: 6485-6492.
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