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Molecules 2010, 15(9), 6476-6484; doi:10.3390/molecules15096476
Communication

Isoquinolines from the Roots of Thalictrum flavum L. and Their Evaluation as Antiparasitic Compounds

1,†, 1,* , 1, 2, 2
 and 1
Received: 15 July 2010; in revised form: 24 August 2010 / Accepted: 13 September 2010 / Published: 16 September 2010
(This article belongs to the Section Metabolites)
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Abstract: Alkaloids from Thalictrum flavum L. (Ranuculaceae) growing in the Loire valley (France) were isolated and evaluated for their antiplasmodial and leishmanicidal activities. Berberine was identified as a major component but its analogue, pseudoberberine, was isolated for the first time from this plant. As far as bisbenzylisoquinolines are concerned, thalfoetidine was also isolated and, besides, its nor- derivative, northalfoetidine, was identified as a new compound. Previously isolated alkaloids from Thalictrum species such as northalidasine, northalrugosidine, thaligosidine, thalicberine, thaliglucinone, preocoteine, O-methylcassythine and armepavine were newly described in the roots of T. flavum. Tertiary isoquinolines, and particularly bisbenzylisoquinolines, were found to be leishmanicidal against L. major. Thalfoetidine appeared as the most potent but its new nor- derivative northalfoetidine, as well as northalidasine, were of particular interest due to the fact that their potential leishmanicidal activity was not associated to a strong cytotoxicity.
Keywords: Antiparasitic; bisbenzylisoquinolines; isoquinoline alkaloids; Ranunculaceae; Thalictrum flavum Antiparasitic; bisbenzylisoquinolines; isoquinoline alkaloids; Ranunculaceae; Thalictrum flavum
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ropivia, J.; Derbré, S.; Rouger, C.; Pagniez, F.; Le Pape, P.; Richomme, P. Isoquinolines from the Roots of Thalictrum flavum L. and Their Evaluation as Antiparasitic Compounds. Molecules 2010, 15, 6476-6484.

AMA Style

Ropivia J, Derbré S, Rouger C, Pagniez F, Le Pape P, Richomme P. Isoquinolines from the Roots of Thalictrum flavum L. and Their Evaluation as Antiparasitic Compounds. Molecules. 2010; 15(9):6476-6484.

Chicago/Turabian Style

Ropivia, Jacqueline; Derbré, Séverine; Rouger, Caroline; Pagniez, Fabrice; Le Pape, Patrice; Richomme, Pascal. 2010. "Isoquinolines from the Roots of Thalictrum flavum L. and Their Evaluation as Antiparasitic Compounds." Molecules 15, no. 9: 6476-6484.


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