Next Article in Journal
Discovery and Development of Anti-HBV Agents and Their Resistance
Previous Article in Journal
Generation and Development of RNA Ligase Ribozymes with Modular Architecture Through “Design and Selection”
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2010, 15(9), 5866-5877; doi:10.3390/molecules15095866

Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits

Pesticide Science Laboratory, Faculty of Agriculture, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Dipartimento Farmaco Chimico Tecnologico, University of Cagliari, via Ospedale 72, 09124 Cagliari, Italy
Bueno, C.A. and Alché, L.E. Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, 4to. Piso, Ciudad Universitaria, Buenos Aires, Argentina
Department of Toxicology, Università degli Studi di Cagliari, via Ospedale 72, 09124 Cagliari, Italy
Author to whom correspondence should be addressed.
Received: 19 July 2010 / Revised: 18 August 2010 / Accepted: 25 August 2010 / Published: 27 August 2010
Download PDF [173 KB, uploaded 18 June 2014]


The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallane-type triterpene, 3-α-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-β-acetoxy-melianone (3), and methyl kulonate (4). The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as HPLC-Q-TOF mass spectrometry. The cytotoxicity of the isolated compounds toward the human lung adenocarcinoma epithelial cell line A549 was determined, while no activity was observed against the phytonematode Meloidogyne incognita.
Keywords: methyl kulonate; 3-α-tigloylmelianol; melianone; 21-β-acetoxy-melianone; cytotoxicity methyl kulonate; 3-α-tigloylmelianol; melianone; 21-β-acetoxy-melianone; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Ntalli, N.G.; Cottiglia, F.; Bueno, C.A.; Alché, L.E.; Leonti, M.; Vargiu, S.; Bifulco, E.; Menkissoglu-Spiroudi, U.; Caboni, P. Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits. Molecules 2010, 15, 5866-5877.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top