Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits
AbstractThe phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallane-type triterpene, 3-α-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-β-acetoxy-melianone (3), and methyl kulonate (4). The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as HPLC-Q-TOF mass spectrometry. The cytotoxicity of the isolated compounds toward the human lung adenocarcinoma epithelial cell line A549 was determined, while no activity was observed against the phytonematode Meloidogyne incognita.
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Ntalli, N.G.; Cottiglia, F.; Bueno, C.A.; Alché, L.E.; Leonti, M.; Vargiu, S.; Bifulco, E.; Menkissoglu-Spiroudi, U.; Caboni, P. Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits. Molecules 2010, 15, 5866-5877.
Ntalli NG, Cottiglia F, Bueno CA, Alché LE, Leonti M, Vargiu S, Bifulco E, Menkissoglu-Spiroudi U, Caboni P. Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits. Molecules. 2010; 15(9):5866-5877.Chicago/Turabian Style
Ntalli, Nikoletta G.; Cottiglia, Filippo; Bueno, Carlos A.; Alché, Laura E.; Leonti, Marco; Vargiu, Simona; Bifulco, Ersilia; Menkissoglu-Spiroudi, Urania; Caboni, Pierluigi. 2010. "Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits." Molecules 15, no. 9: 5866-5877.