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Molecules 2010, 15(9), 5866-5877; doi:10.3390/molecules15095866
Article

Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits

1, 2, 3, 3, 2, 4, 4, 1 and 4,*
Received: 19 July 2010; in revised form: 18 August 2010 / Accepted: 25 August 2010 / Published: 27 August 2010
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Abstract: The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallane-type triterpene, 3-α-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-β-acetoxy-melianone (3), and methyl kulonate (4). The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as HPLC-Q-TOF mass spectrometry. The cytotoxicity of the isolated compounds toward the human lung adenocarcinoma epithelial cell line A549 was determined, while no activity was observed against the phytonematode Meloidogyne incognita.
Keywords: methyl kulonate; 3-α-tigloylmelianol; melianone; 21-β-acetoxy-melianone; cytotoxicity methyl kulonate; 3-α-tigloylmelianol; melianone; 21-β-acetoxy-melianone; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ntalli, N.G.; Cottiglia, F.; Bueno, C.A.; Alché, L.E.; Leonti, M.; Vargiu, S.; Bifulco, E.; Menkissoglu-Spiroudi, U.; Caboni, P. Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits. Molecules 2010, 15, 5866-5877.

AMA Style

Ntalli NG, Cottiglia F, Bueno CA, Alché LE, Leonti M, Vargiu S, Bifulco E, Menkissoglu-Spiroudi U, Caboni P. Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits. Molecules. 2010; 15(9):5866-5877.

Chicago/Turabian Style

Ntalli, Nikoletta G.; Cottiglia, Filippo; Bueno, Carlos A.; Alché, Laura E.; Leonti, Marco; Vargiu, Simona; Bifulco, Ersilia; Menkissoglu-Spiroudi, Urania; Caboni, Pierluigi. 2010. "Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits." Molecules 15, no. 9: 5866-5877.


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