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Molecules 2010, 15(9), 5866-5877; doi:10.3390/molecules15095866

Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits

1
Pesticide Science Laboratory, Faculty of Agriculture, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
2
Dipartimento Farmaco Chimico Tecnologico, University of Cagliari, via Ospedale 72, 09124 Cagliari, Italy
3
Bueno, C.A. and Alché, L.E. Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, 4to. Piso, Ciudad Universitaria, Buenos Aires, Argentina
4
Department of Toxicology, Università degli Studi di Cagliari, via Ospedale 72, 09124 Cagliari, Italy
*
Author to whom correspondence should be addressed.
Received: 19 July 2010 / Revised: 18 August 2010 / Accepted: 25 August 2010 / Published: 27 August 2010
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Abstract

The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallane-type triterpene, 3-α-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-β-acetoxy-melianone (3), and methyl kulonate (4). The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as HPLC-Q-TOF mass spectrometry. The cytotoxicity of the isolated compounds toward the human lung adenocarcinoma epithelial cell line A549 was determined, while no activity was observed against the phytonematode Meloidogyne incognita.
Keywords: methyl kulonate; 3-α-tigloylmelianol; melianone; 21-β-acetoxy-melianone; cytotoxicity methyl kulonate; 3-α-tigloylmelianol; melianone; 21-β-acetoxy-melianone; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Ntalli, N.G.; Cottiglia, F.; Bueno, C.A.; Alché, L.E.; Leonti, M.; Vargiu, S.; Bifulco, E.; Menkissoglu-Spiroudi, U.; Caboni, P. Cytotoxic Tirucallane Triterpenoids from Melia azedarach Fruits. Molecules 2010, 15, 5866-5877.

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