Molecules 2010, 15(8), 5782-5796; doi:10.3390/molecules15085782
Article

Asymmetric Synthesis of α-Aminophosphonates Using the Inexpensive Chiral Catalyst 1,1’-Binaphthol Phosphate

Weiming Xuemail, Sha Zhangemail, Song Yang* email, Lin-Hong Jinemail, Pinaki S. Bhaduryemail, De-Yu Huemail and Yuping Zhangemail
State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China
* Author to whom correspondence should be addressed.
Received: 19 June 2010; in revised form: 18 August 2010 / Accepted: 20 August 2010 / Published: 24 August 2010
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Abstract: Asymmetric addition under mild conditions of dialkyl phosphites on aldimines derived from cinnamaldehyde catalyzed by the inexpensive chiral organocatalyst (R)-3,3’-[4-fluorophenyl]2-1,1’-binaphthol phosphate has been found effective to give new α-amino-phosphonates 9 in moderate yields (30–65%) and enantiomeric excess (8.4%–61.9%).
Keywords: α-aminophosphonate derivatives; aldimines; cinnamaldehyde; chiral organo- catalyst; asymmetric addition

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Cite This Article

MDPI and ACS Style

Xu, W.; Zhang, S.; Yang, S.; Jin, L.-H.; Bhadury, P.S.; Hu, D.-Y.; Zhang, Y. Asymmetric Synthesis of α-Aminophosphonates Using the Inexpensive Chiral Catalyst 1,1’-Binaphthol Phosphate. Molecules 2010, 15, 5782-5796.

AMA Style

Xu W, Zhang S, Yang S, Jin L-H, Bhadury PS, Hu D-Y, Zhang Y. Asymmetric Synthesis of α-Aminophosphonates Using the Inexpensive Chiral Catalyst 1,1’-Binaphthol Phosphate. Molecules. 2010; 15(8):5782-5796.

Chicago/Turabian Style

Xu, Weiming; Zhang, Sha; Yang, Song; Jin, Lin-Hong; Bhadury, Pinaki S.; Hu, De-Yu; Zhang, Yuping. 2010. "Asymmetric Synthesis of α-Aminophosphonates Using the Inexpensive Chiral Catalyst 1,1’-Binaphthol Phosphate." Molecules 15, no. 8: 5782-5796.

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