Molecules 2010, 15(8), 5721-5733; doi:10.3390/molecules15085721
Article

Design, Synthesis, and Biological Evaluation of Benzylamino-Methanone Based Cholesteryl Ester Transfer Protein Inhibitors

Received: 18 June 2010; in revised form: 10 August 2010 / Accepted: 13 August 2010 / Published: 19 August 2010
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Cholesteryl ester transfer protein (CETP) is a glycoprotein involved in transporting lipoprotein particles and neutral lipids between high-density lipoprotein (HDL) and low density lipoproteins (LDL) and therefore its a proper target for treating dyslipidemia and related disorders. Guided by our previosuly-reported pharmacophore and QSAR models for CETP inhibition, we synthesized and bioassayed a series of benzylamino-methanones. The most potent illustrated 30% CETP inhibition at 10 μM.
Keywords: CETP inhibitors; high-density lipoprotein; pharmacophore modeling; quantitative structure-activity relationship; benzylamino-methanones
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MDPI and ACS Style

Sheikha, G.A.; Abu Khalaf, R.; Melhem, A.; Albadawi, G. Design, Synthesis, and Biological Evaluation of Benzylamino-Methanone Based Cholesteryl Ester Transfer Protein Inhibitors. Molecules 2010, 15, 5721-5733.

AMA Style

Sheikha GA, Abu Khalaf R, Melhem A, Albadawi G. Design, Synthesis, and Biological Evaluation of Benzylamino-Methanone Based Cholesteryl Ester Transfer Protein Inhibitors. Molecules. 2010; 15(8):5721-5733.

Chicago/Turabian Style

Sheikha, Ghassan Abu; Abu Khalaf, Reema; Melhem, Areej; Albadawi, Ghadeer. 2010. "Design, Synthesis, and Biological Evaluation of Benzylamino-Methanone Based Cholesteryl Ester Transfer Protein Inhibitors." Molecules 15, no. 8: 5721-5733.

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