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Molecules 2010, 15(8), 5671-5679; doi:10.3390/molecules15085671
Communication

Synthesis, Identification and Anti-Cancer Activity of 1-(4-Methylpent-2-enyl)-2-(4-phenylbut-2-enyl)disulfane

1
, 1,*  and 2
Received: 8 July 2010; in revised form: 5 August 2010 / Accepted: 9 August 2010 / Published: 16 August 2010
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Abstract: In this study, we synthesized 1-(4-methylpent-2-enyl)-2-(4-phenylbut-2- enyl)disulfane using sodium sulfide, 1-bromine-4-methyl-2-amylene and 1-(4-bromine-2- butylene)benzene as raw materials. The yield rate of target product was 84%. The structure of the target product was confirmed by GC-MS, 1H-NMR and elemental analysis. The results of anti-cancer activity experiments showed that 1-(4-methylpent-2-enyl)-2-(4- phenylbut-2-enyl)disul-fane could significantly inhibit the proliferation, induce the apoptosis of CNE2 cells in a dose dependent manner, and could significantly enhance the activity of XIAP.
Keywords: 1-(4-methylpent-2-enyl)-2-(4-phenylbut-2-enyl)disulfane; synthesis; anti-cancer activity; XIAP 1-(4-methylpent-2-enyl)-2-(4-phenylbut-2-enyl)disulfane; synthesis; anti-cancer activity; XIAP
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ji, C.; Ren, F.; Xu, M. Synthesis, Identification and Anti-Cancer Activity of 1-(4-Methylpent-2-enyl)-2-(4-phenylbut-2-enyl)disulfane. Molecules 2010, 15, 5671-5679.

AMA Style

Ji C, Ren F, Xu M. Synthesis, Identification and Anti-Cancer Activity of 1-(4-Methylpent-2-enyl)-2-(4-phenylbut-2-enyl)disulfane. Molecules. 2010; 15(8):5671-5679.

Chicago/Turabian Style

Ji, Chunxiao; Ren, Fenglian; Xu, Ming. 2010. "Synthesis, Identification and Anti-Cancer Activity of 1-(4-Methylpent-2-enyl)-2-(4-phenylbut-2-enyl)disulfane." Molecules 15, no. 8: 5671-5679.


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