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Molecules 2010, 15(8), 5671-5679; doi:10.3390/molecules15085671

Synthesis, Identification and Anti-Cancer Activity of 1-(4-Methylpent-2-enyl)-2-(4-phenylbut-2-enyl)disulfane

1
College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China
2
Research Institute for Molecular Pharmacology and Therapeutics, Central South University, Changsha, Hunan 410083, China
*
Author to whom correspondence should be addressed.
Received: 8 July 2010 / Revised: 5 August 2010 / Accepted: 9 August 2010 / Published: 16 August 2010
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Abstract

In this study, we synthesized 1-(4-methylpent-2-enyl)-2-(4-phenylbut-2- enyl)disulfane using sodium sulfide, 1-bromine-4-methyl-2-amylene and 1-(4-bromine-2- butylene)benzene as raw materials. The yield rate of target product was 84%. The structure of the target product was confirmed by GC-MS, 1H-NMR and elemental analysis. The results of anti-cancer activity experiments showed that 1-(4-methylpent-2-enyl)-2-(4- phenylbut-2-enyl)disul-fane could significantly inhibit the proliferation, induce the apoptosis of CNE2 cells in a dose dependent manner, and could significantly enhance the activity of XIAP.
Keywords: 1-(4-methylpent-2-enyl)-2-(4-phenylbut-2-enyl)disulfane; synthesis; anti-cancer activity; XIAP 1-(4-methylpent-2-enyl)-2-(4-phenylbut-2-enyl)disulfane; synthesis; anti-cancer activity; XIAP
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Ji, C.; Ren, F.; Xu, M. Synthesis, Identification and Anti-Cancer Activity of 1-(4-Methylpent-2-enyl)-2-(4-phenylbut-2-enyl)disulfane. Molecules 2010, 15, 5671-5679.

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