Next Article in Journal
Solid-Phase Synthesis of Oligodeoxynucleotides Containing N4-[2-(t-butyldisulfanyl)ethyl]-5-methylcytosine Moieties
Previous Article in Journal
Synthesis, Identification and Anti-Cancer Activity of 1-(4-Methylpent-2-enyl)-2-(4-phenylbut-2-enyl)disulfane
Molecules 2010, 15(8), 5680-5691; doi:10.3390/molecules15085680
Article

A Facile Synthesis of 3-Substituted 9H-Pyrido[3,4-b]indol-1(2H)-one Derivatives from 3-Substituted β-Carbolines

1, 1,* , 1, 1, 1 and 1,2,*
1 College of Basic Science, China Pharmaceutical University, Nanjing 210009, China 2 Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China
* Authors to whom correspondence should be addressed.
Received: 2 August 2010 / Revised: 10 August 2010 / Accepted: 11 August 2010 / Published: 17 August 2010
Download PDF [369 KB, 18 June 2014; original version 18 June 2014]

Abstract

A mild and efficient two-step synthesis of 3-substituted β-carbolinone derivatives from 3-substituted β-carboline in good yields is described. A possible reaction mechanism for the formation of the skeleton of β-carbolin-1-one is proposed. The structures of these compounds were established by IR, 1H-NMR, 13C-NMR, mass spectrometry and elemental analysis, as well as X-ray crystallographic analysis of 4-2 and 6-2.
Keywords: β-carboline; β-carbolinone; rearrangement; electron-withdrawing; X-ray crystal structure. β-carboline; β-carbolinone; rearrangement; electron-withdrawing; X-ray crystal structure.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Lin, G.; Wang, Y.; Zhou, Q.; Tang, W.; Wang, J.; Lu, T. A Facile Synthesis of 3-Substituted 9H-Pyrido[3,4-b]indol-1(2H)-one Derivatives from 3-Substituted β-Carbolines. Molecules 2010, 15, 5680-5691.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert