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Molecules 2010, 15(8), 5680-5691; doi:10.3390/molecules15085680
Article

A Facile Synthesis of 3-Substituted 9H-Pyrido[3,4-b]indol-1(2H)-one Derivatives from 3-Substituted β-Carbolines

1, 1,* , 1, 1, 1 and 1,2,*
Received: 2 August 2010 / Revised: 10 August 2010 / Accepted: 11 August 2010 / Published: 17 August 2010
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Abstract

A mild and efficient two-step synthesis of 3-substituted β-carbolinone derivatives from 3-substituted β-carboline in good yields is described. A possible reaction mechanism for the formation of the skeleton of β-carbolin-1-one is proposed. The structures of these compounds were established by IR, 1H-NMR, 13C-NMR, mass spectrometry and elemental analysis, as well as X-ray crystallographic analysis of 4-2 and 6-2.
Keywords: β-carboline; β-carbolinone; rearrangement; electron-withdrawing; X-ray crystal structure. β-carboline; β-carbolinone; rearrangement; electron-withdrawing; X-ray crystal structure.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Lin, G.; Wang, Y.; Zhou, Q.; Tang, W.; Wang, J.; Lu, T. A Facile Synthesis of 3-Substituted 9H-Pyrido[3,4-b]indol-1(2H)-one Derivatives from 3-Substituted β-Carbolines. Molecules 2010, 15, 5680-5691.

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