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Molecules 2010, 15(7), 4898-4907; doi:10.3390/molecules15074898

Antifungal Activity of Extracts and Prenylated Coumarins Isolated from Baccharis darwinii Hook & Arn. (Asteraceae)

3, 3, 3
1 Laboratorio de Productos Naturales Patagónicos (LAPRONAP), Facultad de Ciencias Naturales, Universidad Nacional de la Patagonia San Juan Bosco, Km 4, CP 9000, Comodoro Rivadavia, Chubut, Argentina 2 Instituto de Biotecnología - Instituto de Ciencias Básicas, Universidad Nacional de San Juan, Av. Libertador General San Martín 1109 (O), CP5400, San Juan, Argentina 3 Facultad de Ciencias Bioquímicas y Farmacéuticas, Farmacognosia y Biología Vegetal. Universidad Nacional de Rosario, Suipacha 531, CP2000, Rosario, Argentina 4 Facultad de Química, Bioquímica y Farmacia. Universidad Nacional de San Luis, Chacabuco 917, CP5700, San Luis, Argentina
* Author to whom correspondence should be addressed.
Received: 17 June 2010 / Revised: 1 July 2010 / Accepted: 7 July 2010 / Published: 13 July 2010
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The petroleum ether extract of Baccharis darwinii showed activity against Cryptococcus neoformans and dermatophytes. Bioactivity-guided fractionation of Baccharis darwinii has resulted in the isolation of three coumarins: 5’-hydroxy aurapten (anisocoumarin H, 1), aurapten (7-geranyloxycoumarin, 2) and 5’-oxoaurapten (diversinin, 3). The structures of these compounds were characterized by spectroscopic methods. These compounds were evaluated for their antimicrobialactivity against a panel of each, bacteria and fungi. Compound 3 showed the best activities against Microsporum gypseum, Trichophyton rubrum and Trichophyton mentagrophytes with MICs = 15.6 µg/mL, followed by compound 1 whose MICs against the same fungi were 62.5 µg/mL. In addition they showed fungicidal rather than fungistatic activity. Both compounds showed moderate activity (MICs = 125 µg/mL) against Cryptococcus neoformans. This is the first report of the presence of compound 1 in B. darwinii.
Keywords: Baccharis darwinii; Asteraceae; prenylated coumarins; auraptene; antimicrobial activity Baccharis darwinii; Asteraceae; prenylated coumarins; auraptene; antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kurdelas, R.R.; Lima, B.; Tapia, A.; Egly Feresin, G.; Gonzalez Sierra, M.; Rodríguez, M.V.; Zacchino, S.; Enriz, R.D.; Freile, M.L. Antifungal Activity of Extracts and Prenylated Coumarins Isolated from Baccharis darwinii Hook & Arn. (Asteraceae). Molecules 2010, 15, 4898-4907.

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