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Molecules 2010, 15(7), 4898-4907; doi:10.3390/molecules15074898

Antifungal Activity of Extracts and Prenylated Coumarins Isolated from Baccharis darwinii Hook & Arn. (Asteraceae)

Laboratorio de Productos Naturales Patagónicos (LAPRONAP), Facultad de Ciencias Naturales, Universidad Nacional de la Patagonia San Juan Bosco, Km 4, CP 9000, Comodoro Rivadavia, Chubut, Argentina
Instituto de Biotecnología - Instituto de Ciencias Básicas, Universidad Nacional de San Juan, Av. Libertador General San Martín 1109 (O), CP5400, San Juan, Argentina
Facultad de Ciencias Bioquímicas y Farmacéuticas, Farmacognosia y Biología Vegetal. Universidad Nacional de Rosario, Suipacha 531, CP2000, Rosario, Argentina
Facultad de Química, Bioquímica y Farmacia. Universidad Nacional de San Luis, Chacabuco 917, CP5700, San Luis, Argentina
Author to whom correspondence should be addressed.
Received: 17 June 2010 / Revised: 1 July 2010 / Accepted: 7 July 2010 / Published: 13 July 2010
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The petroleum ether extract of Baccharis darwinii showed activity against Cryptococcus neoformans and dermatophytes. Bioactivity-guided fractionation of Baccharis darwinii has resulted in the isolation of three coumarins: 5’-hydroxy aurapten (anisocoumarin H, 1), aurapten (7-geranyloxycoumarin, 2) and 5’-oxoaurapten (diversinin, 3). The structures of these compounds were characterized by spectroscopic methods. These compounds were evaluated for their antimicrobialactivity against a panel of each, bacteria and fungi. Compound 3 showed the best activities against Microsporum gypseum, Trichophyton rubrum and Trichophyton mentagrophytes with MICs = 15.6 µg/mL, followed by compound 1 whose MICs against the same fungi were 62.5 µg/mL. In addition they showed fungicidal rather than fungistatic activity. Both compounds showed moderate activity (MICs = 125 µg/mL) against Cryptococcus neoformans. This is the first report of the presence of compound 1 in B. darwinii.
Keywords: Baccharis darwinii; Asteraceae; prenylated coumarins; auraptene; antimicrobial activity Baccharis darwinii; Asteraceae; prenylated coumarins; auraptene; antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Kurdelas, R.R.; Lima, B.; Tapia, A.; Egly Feresin, G.; Gonzalez Sierra, M.; Rodríguez, M.V.; Zacchino, S.; Enriz, R.D.; Freile, M.L. Antifungal Activity of Extracts and Prenylated Coumarins Isolated from Baccharis darwinii Hook & Arn. (Asteraceae). Molecules 2010, 15, 4898-4907.

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