Abstract: The petroleum ether extract of Baccharis darwinii showed activity against Cryptococcus neoformans and dermatophytes. Bioactivity-guided fractionation of Baccharis darwinii has resulted in the isolation of three coumarins: 5’-hydroxy aurapten (anisocoumarin H, 1), aurapten (7-geranyloxycoumarin, 2) and 5’-oxoaurapten (diversinin, 3). The structures of these compounds were characterized by spectroscopic methods. These compounds were evaluated for their antimicrobialactivity against a panel of each, bacteria and fungi. Compound 3 showed the best activities against Microsporum gypseum, Trichophyton rubrum and Trichophyton mentagrophytes with MICs = 15.6 µg/mL, followed by compound 1 whose MICs against the same fungi were 62.5 µg/mL. In addition they showed fungicidal rather than fungistatic activity. Both compounds showed moderate activity (MICs = 125 µg/mL) against Cryptococcus neoformans. This is the first report of the presence of compound 1 in B. darwinii.
Keywords: Baccharis darwinii; Asteraceae; prenylated coumarins; auraptene; antimicrobial activity
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Kurdelas, R.R.; Lima, B.; Tapia, A.; Egly Feresin, G.; Gonzalez Sierra, M.; Rodríguez, M.V.; Zacchino, S.; Enriz, R.D.; Freile, M.L. Antifungal Activity of Extracts and Prenylated Coumarins Isolated from Baccharis darwinii Hook & Arn. (Asteraceae). Molecules 2010, 15, 4898-4907.
Kurdelas RR, Lima B, Tapia A, Egly Feresin G, Gonzalez Sierra M, Rodríguez MV, Zacchino S, Enriz RD, Freile ML. Antifungal Activity of Extracts and Prenylated Coumarins Isolated from Baccharis darwinii Hook & Arn. (Asteraceae). Molecules. 2010; 15(7):4898-4907.
Kurdelas, Rita R.; Lima, Beatriz; Tapia, Alejandro; Egly Feresin, Gabriela; Gonzalez Sierra, Manuel; Rodríguez, María Victoria; Zacchino, Susana; Enriz, Ricardo D.; Freile, Monica L. 2010. "Antifungal Activity of Extracts and Prenylated Coumarins Isolated from Baccharis darwinii Hook & Arn. (Asteraceae)." Molecules 15, no. 7: 4898-4907.