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Molecules 2010, 15(6), 3998-4010; doi:10.3390/molecules15063998
Article

Direct Enzymatic Route for the Preparation of Novel Enantiomerically Enriched Hydroxylated β-Amino Ester Stereoisomers

1, 1, 1, 2, 2 and 1,3,*
1 Institute of Pharmaceutical Chemistry, University of Szeged, H-6720 Szeged, Eötvös u. 6, Hungary 2 Departamento de Química, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Av. Instituto Politécnico Nacional 2508 Col. San Pedro Zacatenco, 07360 México, D.F. Apartado Postal 14-740, 07000, D.F., Mexico 3 Research Group of Stereochemistry of the Hungarian Academy of Sciences, University of Szeged, H-6720 Szeged, Eötvös u. 6, Hungary
* Author to whom correspondence should be addressed.
Received: 6 May 2010 / Revised: 25 May 2010 / Accepted: 28 May 2010 / Published: 1 June 2010
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Abstract

Enantiomerically enriched hydroxy-substituted b-amino esters have been synthesized through CAL-B-catalyzed enantioselective hydrolysis in organic media. Moderate to good enantiomeric excess values (ee ≥ 52%) were obtained when the CAL-B-catalyzed reactions were performed in t-BuOMe, at 60 ºC with 0.5 equiv. of added H2O as nucleophile.
Keywords: β-amino ester; stereoisomer; enzyme; hydrolysis; hydroxylation; organic solvent; enantioselective β-amino ester; stereoisomer; enzyme; hydrolysis; hydroxylation; organic solvent; enantioselective
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Forró, E.; Schönstein, L.; Kiss, L.; Vega-Peñaloza, A.; Juaristi, E.; Fülöp, F. Direct Enzymatic Route for the Preparation of Novel Enantiomerically Enriched Hydroxylated β-Amino Ester Stereoisomers. Molecules 2010, 15, 3998-4010.

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