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Molecules 2010, 15(6), 3998-4010; doi:10.3390/molecules15063998
Article

Direct Enzymatic Route for the Preparation of Novel Enantiomerically Enriched Hydroxylated β-Amino Ester Stereoisomers

1, 1, 1, 2, 2 and 1,3,*
Received: 6 May 2010 / Revised: 25 May 2010 / Accepted: 28 May 2010 / Published: 1 June 2010
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Abstract

Enantiomerically enriched hydroxy-substituted b-amino esters have been synthesized through CAL-B-catalyzed enantioselective hydrolysis in organic media. Moderate to good enantiomeric excess values (ee ≥ 52%) were obtained when the CAL-B-catalyzed reactions were performed in t-BuOMe, at 60 ºC with 0.5 equiv. of added H2O as nucleophile.
Keywords: β-amino ester; stereoisomer; enzyme; hydrolysis; hydroxylation; organic solvent; enantioselective β-amino ester; stereoisomer; enzyme; hydrolysis; hydroxylation; organic solvent; enantioselective
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Forró, E.; Schönstein, L.; Kiss, L.; Vega-Peñaloza, A.; Juaristi, E.; Fülöp, F. Direct Enzymatic Route for the Preparation of Novel Enantiomerically Enriched Hydroxylated β-Amino Ester Stereoisomers. Molecules 2010, 15, 3998-4010.

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