Next Article in Journal
Aquilarin A, a New Benzenoid Derivative from the Fresh Stem of Aquilaria sinensis
Previous Article in Journal
A New Azaphilone, Kasanosin C, from an Endophytic Talaromyces sp. T1BF
Molecules 2010, 15(6), 3998-4010; doi:10.3390/molecules15063998
Article

Direct Enzymatic Route for the Preparation of Novel Enantiomerically Enriched Hydroxylated β-Amino Ester Stereoisomers

1, 1, 1, 2, 2 and 1,3,*
1 Institute of Pharmaceutical Chemistry, University of Szeged, H-6720 Szeged, Eötvös u. 6, Hungary 2 Departamento de Química, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Av. Instituto Politécnico Nacional 2508 Col. San Pedro Zacatenco, 07360 México, D.F. Apartado Postal 14-740, 07000, D.F., Mexico 3 Research Group of Stereochemistry of the Hungarian Academy of Sciences, University of Szeged, H-6720 Szeged, Eötvös u. 6, Hungary
* Author to whom correspondence should be addressed.
Received: 6 May 2010 / Revised: 25 May 2010 / Accepted: 28 May 2010 / Published: 1 June 2010
Download PDF [585 KB, uploaded 18 June 2014]

Abstract

Enantiomerically enriched hydroxy-substituted b-amino esters have been synthesized through CAL-B-catalyzed enantioselective hydrolysis in organic media. Moderate to good enantiomeric excess values (ee ≥ 52%) were obtained when the CAL-B-catalyzed reactions were performed in t-BuOMe, at 60 ºC with 0.5 equiv. of added H2O as nucleophile.
Keywords: β-amino ester; stereoisomer; enzyme; hydrolysis; hydroxylation; organic solvent; enantioselective β-amino ester; stereoisomer; enzyme; hydrolysis; hydroxylation; organic solvent; enantioselective
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Forró, E.; Schönstein, L.; Kiss, L.; Vega-Peñaloza, A.; Juaristi, E.; Fülöp, F. Direct Enzymatic Route for the Preparation of Novel Enantiomerically Enriched Hydroxylated β-Amino Ester Stereoisomers. Molecules 2010, 15, 3998-4010.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert