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Molecules 2010, 15(5), 3757-3774; doi:10.3390/molecules15053757

Photochemical Transformations of Tetrazole Derivatives: Applications in Organic Synthesis

CQFM - Centro de Química-Física Molecular, IN - Institute of Nanoscience and Nanotechnology, Departamento de Engenharia Química e Biológica, Instituto Superior Técnico, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal
Departmento de Química e Farmácia, FCT, and CCMAR, Universidade do Algarve, Campus de Gambelas, 8005-039 Faro, Portugal
Author to whom correspondence should be addressed.
Received: 8 April 2010 / Revised: 1 May 2010 / Accepted: 21 May 2010 / Published: 25 May 2010
(This article belongs to the Special Issue Photochemistry in Organic Synthesis)
Download PDF [248 KB, uploaded 18 June 2014]


Tetrazoles remain a challenge to photochemists. Photolysis leads to cleavage of the tetrazolyl ring, may involve various photodegradation pathways and may produce a diversity of photoproducts, depending on the structure and conformational flexibility of the substituents and the possibility of tautomerism. If the photochemistry of tetrazoles is considered within the frame of synthetic applications the subject is even more challenging, since the ultimate goal is to achieve selectivity and high yield. In addition, the photoproducts must remain stable and allow isolation or trapping, in order to be used in other reactions. This review summarises the photochemical transformations of tetrazole derivatives that can be used as effective synthetic routes to other compounds.
Keywords: tetrazoles; photochemistry; UV-irradiation; nitrogen heterocyles; synthesis tetrazoles; photochemistry; UV-irradiation; nitrogen heterocyles; synthesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Frija, L.M.T.; Ismael, A.; Cristiano, M.L.S. Photochemical Transformations of Tetrazole Derivatives: Applications in Organic Synthesis. Molecules 2010, 15, 3757-3774.

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