Molecules 2010, 15(5), 3757-3774; doi:10.3390/molecules15053757
Review

Photochemical Transformations of Tetrazole Derivatives: Applications in Organic Synthesis

1 CQFM - Centro de Química-Física Molecular, IN - Institute of Nanoscience and Nanotechnology, Departamento de Engenharia Química e Biológica, Instituto Superior Técnico, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal 2 Departmento de Química e Farmácia, FCT, and CCMAR, Universidade do Algarve, Campus de Gambelas, 8005-039 Faro, Portugal
* Author to whom correspondence should be addressed.
Received: 8 April 2010; in revised form: 1 May 2010 / Accepted: 21 May 2010 / Published: 25 May 2010
(This article belongs to the Special Issue Photochemistry in Organic Synthesis)
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Abstract: Tetrazoles remain a challenge to photochemists. Photolysis leads to cleavage of the tetrazolyl ring, may involve various photodegradation pathways and may produce a diversity of photoproducts, depending on the structure and conformational flexibility of the substituents and the possibility of tautomerism. If the photochemistry of tetrazoles is considered within the frame of synthetic applications the subject is even more challenging, since the ultimate goal is to achieve selectivity and high yield. In addition, the photoproducts must remain stable and allow isolation or trapping, in order to be used in other reactions. This review summarises the photochemical transformations of tetrazole derivatives that can be used as effective synthetic routes to other compounds.
Keywords: tetrazoles; photochemistry; UV-irradiation; nitrogen heterocyles; synthesis

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MDPI and ACS Style

Frija, L.M.T.; Ismael, A.; Cristiano, M.L.S. Photochemical Transformations of Tetrazole Derivatives: Applications in Organic Synthesis. Molecules 2010, 15, 3757-3774.

AMA Style

Frija LMT, Ismael A, Cristiano MLS. Photochemical Transformations of Tetrazole Derivatives: Applications in Organic Synthesis. Molecules. 2010; 15(5):3757-3774.

Chicago/Turabian Style

Frija, Luís Miguel Teodoro; Ismael, Amin; Cristiano, Maria Lurdes Santos. 2010. "Photochemical Transformations of Tetrazole Derivatives: Applications in Organic Synthesis." Molecules 15, no. 5: 3757-3774.

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