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Molecules 2010, 15(5), 3602-3617; doi:10.3390/molecules15053602
Article

The Reaction of Cyanoacetylhydrazine with ω-Bromo(4-methyl)acetophenone: Synthesis of Heterocyclic Derivatives with Antitumor Activity

1,2,*  and 3
Received: 22 March 2010 / Revised: 14 April 2010 / Accepted: 21 April 2010 / Published: 17 May 2010
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Abstract

New approaches for the synthesis of hydrazide-hydrazone derivatives were demonstrated as well as some heterocyclizations of such derivatives to afford 1,3,4-triazine, pyridine and 1,3,4-oxadiazine derivatives. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Most of the synthesized compounds showed high inhibitory effects.
Keywords: hydrazide-hydrazone; 1,3,4-triazine; pyridine; pyridazine; antitumor hydrazide-hydrazone; 1,3,4-triazine; pyridine; pyridazine; antitumor
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mohareb, R.M.; Mohamed, A.A. The Reaction of Cyanoacetylhydrazine with ω-Bromo(4-methyl)acetophenone: Synthesis of Heterocyclic Derivatives with Antitumor Activity. Molecules 2010, 15, 3602-3617.

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