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Molecules 2010, 15(5), 3602-3617; doi:10.3390/molecules15053602
Article

The Reaction of Cyanoacetylhydrazine with ω-Bromo(4-methyl)acetophenone: Synthesis of Heterocyclic Derivatives with Antitumor Activity

1,2,*  and 3
1 Department of Organic Chemistry, Faculty of Pharmacy, October University for Modern Sciences and Arts, October City, A.R., Egypt 2 Department of Chemistry, Faculty of Science, Cairo University, Giza, A.R., Egypt 3 National Organization for Drug Control & Research (NODCAR), P.O. 29, Cairo, Egypt
* Author to whom correspondence should be addressed.
Received: 22 March 2010 / Revised: 14 April 2010 / Accepted: 21 April 2010 / Published: 17 May 2010
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Abstract

New approaches for the synthesis of hydrazide-hydrazone derivatives were demonstrated as well as some heterocyclizations of such derivatives to afford 1,3,4-triazine, pyridine and 1,3,4-oxadiazine derivatives. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Most of the synthesized compounds showed high inhibitory effects.
Keywords: hydrazide-hydrazone; 1,3,4-triazine; pyridine; pyridazine; antitumor hydrazide-hydrazone; 1,3,4-triazine; pyridine; pyridazine; antitumor
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Mohareb, R.M.; Mohamed, A.A. The Reaction of Cyanoacetylhydrazine with ω-Bromo(4-methyl)acetophenone: Synthesis of Heterocyclic Derivatives with Antitumor Activity. Molecules 2010, 15, 3602-3617.

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