Next Article in Journal
Synthesis and Spectrosopic Identification of Hybrid 3-(Triethoxysilyl)propylamine Phosphine Ruthenium(II) Complexes
Previous Article in Journal
Microwave-Assisted One-Pot Synthesis of Pyrazolone Derivatives under Solvent-Free Conditions
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2010, 15(5), 3602-3617; doi:10.3390/molecules15053602

The Reaction of Cyanoacetylhydrazine with ω-Bromo(4-methyl)acetophenone: Synthesis of Heterocyclic Derivatives with Antitumor Activity

1
Department of Organic Chemistry, Faculty of Pharmacy, October University for Modern Sciences and Arts, October City, A.R., Egypt
2
Department of Chemistry, Faculty of Science, Cairo University, Giza, A.R., Egypt
3
National Organization for Drug Control & Research (NODCAR), P.O. 29, Cairo, Egypt
*
Author to whom correspondence should be addressed.
Received: 22 March 2010 / Revised: 14 April 2010 / Accepted: 21 April 2010 / Published: 17 May 2010
Download PDF [413 KB, uploaded 18 June 2014]

Abstract

New approaches for the synthesis of hydrazide-hydrazone derivatives were demonstrated as well as some heterocyclizations of such derivatives to afford 1,3,4-triazine, pyridine and 1,3,4-oxadiazine derivatives. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Most of the synthesized compounds showed high inhibitory effects.
Keywords: hydrazide-hydrazone; 1,3,4-triazine; pyridine; pyridazine; antitumor hydrazide-hydrazone; 1,3,4-triazine; pyridine; pyridazine; antitumor
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Mohareb, R.M.; Mohamed, A.A. The Reaction of Cyanoacetylhydrazine with ω-Bromo(4-methyl)acetophenone: Synthesis of Heterocyclic Derivatives with Antitumor Activity. Molecules 2010, 15, 3602-3617.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top