Microwave-Assisted One-Pot Synthesis of Pyrazolone Derivatives under Solvent-Free Conditions

doi:10.3390/molecules15053593

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Molecules 2010, 15(5), 3593-3601; doi:10.3390/molecules15053593

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Microwave-Assisted One-Pot Synthesis of Pyrazolone Derivatives under Solvent-Free Conditions

Ruoqun Ma¹, Jin Zhu¹, Jie Liu¹, Lili Chen^2,* , Xu Shen^1,2, Hualiang Jiang^1,2,3 and Jian Li^1,2,*

¹ School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China ² State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China ³ Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China

* Authors to whom correspondence should be addressed.

Received: 23 April 2010; in revised form: 10 May 2010 / Accepted: 13 May 2010 / Published: 17 May 2010

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Abstract: An efficient one-pot method to generate structurally diverse and medicinally interesting pyrazolone derivatives in good to excellent yields of 51–98% under microwave irradiation and solvent-free conditions has been developed.

Keywords: microwave-assisted reactions; one-pot; pyrazolones

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MDPI and ACS Style

Ma, R.; Zhu, J.; Liu, J.; Chen, L.; Shen, X.; Jiang, H.; Li, J. Microwave-Assisted One-Pot Synthesis of Pyrazolone Derivatives under Solvent-Free Conditions. Molecules 2010, 15, 3593-3601.

AMA Style

Ma R, Zhu J, Liu J, Chen L, Shen X, Jiang H, Li J. Microwave-Assisted One-Pot Synthesis of Pyrazolone Derivatives under Solvent-Free Conditions. Molecules. 2010; 15(5):3593-3601.

Chicago/Turabian Style

Ma, Ruoqun; Zhu, Jin; Liu, Jie; Chen, Lili; Shen, Xu; Jiang, Hualiang; Li, Jian. 2010. "Microwave-Assisted One-Pot Synthesis of Pyrazolone Derivatives under Solvent-Free Conditions." Molecules 15, no. 5: 3593-3601.

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