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Antifungal Effect of (+)-Pinoresinol Isolated from Sambucus williamsii
AbstractIn this study, we investigated the antifungal activity and mechanism of action of (+)-pinoresinol, a biphenolic compound isolated from the herb Sambucus williamsii,used in traditional medicine. (+)-Pinoresinol displays potent antifungal properties without hemolytic effects on human erythrocytes. To understand the antifungal mechanism of (+)-pinoresinol, we conducted fluorescence experiments on the human pathogen Candida albicans. Fluorescence analysis using 1,6-diphenyl-1,3,5-hexatriene (DPH) indicated that the (+)-pinoresinol caused damage to the fungal plasma membrane. This result was confirmed by using rhodamine-labeled giant unilamellar vesicle (GUV) experiments. Therefore, the present study indicates that (+)-pinoresinol possesses fungicidal activities and therapeutic potential as an antifungal agent for the treatment of fungal infectious diseases in humans.
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Hwang, B.; Lee, J.; Liu, Q.-H.; Woo, E.-R.; Lee, D.G. Antifungal Effect of (+)-Pinoresinol Isolated from Sambucus williamsii. Molecules 2010, 15, 3507-3516.View more citation formats
Hwang B, Lee J, Liu Q-H, Woo E-R, Lee DG. Antifungal Effect of (+)-Pinoresinol Isolated from Sambucus williamsii. Molecules. 2010; 15(5):3507-3516.Chicago/Turabian Style
Hwang, Bomi; Lee, Juneyoung; Liu, Qing-He; Woo, Eun-Rhan; Lee, Dong Gun. 2010. "Antifungal Effect of (+)-Pinoresinol Isolated from Sambucus williamsii." Molecules 15, no. 5: 3507-3516.