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Molecules 2010, 15(5), 3507-3516; doi:10.3390/molecules15053507

Antifungal Effect of (+)-Pinoresinol Isolated from Sambucus williamsii

1 School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, 1370 Sankyuk-dong, Puk-ku, Daegu 702-701, Korea 2 College of Pharmacy, Chosun University, 375 Seosuk-dong, Dong-gu, Gwangju 501-759, Korea
* Author to whom correspondence should be addressed.
Received: 9 April 2010 / Revised: 6 May 2010 / Accepted: 11 May 2010 / Published: 14 May 2010
(This article belongs to the Special Issue Anti-Infective Agents)
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In this study, we investigated the antifungal activity and mechanism of action of (+)-pinoresinol, a biphenolic compound isolated from the herb Sambucus williamsii,used in traditional medicine. (+)-Pinoresinol displays potent antifungal properties without hemolytic effects on human erythrocytes. To understand the antifungal mechanism of (+)-pinoresinol, we conducted fluorescence experiments on the human pathogen Candida albicans. Fluorescence analysis using 1,6-diphenyl-1,3,5-hexatriene (DPH) indicated that the (+)-pinoresinol caused damage to the fungal plasma membrane. This result was confirmed by using rhodamine-labeled giant unilamellar vesicle (GUV) experiments. Therefore, the present study indicates that (+)-pinoresinol possesses fungicidal activities and therapeutic potential as an antifungal agent for the treatment of fungal infectious diseases in humans.
Keywords: (+)-pinoresinol; lignan; antifungal compound; membrane-active mechanism; Sambucus williamsii HANCE (+)-pinoresinol; lignan; antifungal compound; membrane-active mechanism; Sambucus williamsii HANCE
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hwang, B.; Lee, J.; Liu, Q.-H.; Woo, E.-R.; Lee, D.G. Antifungal Effect of (+)-Pinoresinol Isolated from Sambucus williamsii. Molecules 2010, 15, 3507-3516.

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