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Molecules 2010, 15(5), 3276-3280; doi:10.3390/molecules15053276
Article

A Facile One-Pot Synthesis of α-Bromo-α,β-unsaturated Esters from Alcohols

* , ,  and
Chemistry Department, College of Science, King Saud University, P.O. Box 2455 Riyadh 11451, Saudi Arabia
* Author to whom correspondence should be addressed.
Received: 9 March 2010 / Revised: 27 April 2010 / Accepted: 29 April 2010 / Published: 4 May 2010
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Abstract

Treatment ofN-bromosuccinimide (NBS) with (carboethoxymethylene) triphenylphosphorane (1) in CH2Cl2 followed by the addition of an alcohol in the presence of manganese dioxide under ultrasonic irradiation constitutes a stereoselective one-pot procedure for the preparation of Z-configured α–bromo-α,β-unsaturated esters in good to excellent yield.
Keywords: one-pot synthesis; bromoylides; oxidation; α–bromo-α,β-unsaturated esters one-pot synthesis; bromoylides; oxidation; α–bromo-α,β-unsaturated esters
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Karama, U.; Al-Othman, Z.; Al-Majid, A.; Almansour, A. A Facile One-Pot Synthesis of α-Bromo-α,β-unsaturated Esters from Alcohols. Molecules 2010, 15, 3276-3280.

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