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Molecules 2010, 15(5), 3276-3280; doi:10.3390/molecules15053276

A Facile One-Pot Synthesis of α-Bromo-α,β-unsaturated Esters from Alcohols

Chemistry Department, College of Science, King Saud University, P.O. Box 2455 Riyadh 11451, Saudi Arabia
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Received: 9 March 2010 / Revised: 27 April 2010 / Accepted: 29 April 2010 / Published: 4 May 2010
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Abstract

Treatment ofN-bromosuccinimide (NBS) with (carboethoxymethylene) triphenylphosphorane (1) in CH2Cl2 followed by the addition of an alcohol in the presence of manganese dioxide under ultrasonic irradiation constitutes a stereoselective one-pot procedure for the preparation of Z-configured α–bromo-α,β-unsaturated esters in good to excellent yield.
Keywords: one-pot synthesis; bromoylides; oxidation; α–bromo-α,β-unsaturated esters one-pot synthesis; bromoylides; oxidation; α–bromo-α,β-unsaturated esters
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Karama, U.; Al-Othman, Z.; Al-Majid, A.; Almansour, A. A Facile One-Pot Synthesis of α-Bromo-α,β-unsaturated Esters from Alcohols. Molecules 2010, 15, 3276-3280.

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