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Molecules 2010, 15(5), 3121-3134; doi:10.3390/molecules15053121
Article

Synthesis of N-(Methoxycarbonylthienylmethyl)thioureas and Evaluation of Their Interaction with Inducible and Neuronal Nitric Oxide Synthase

1,* , 2 and 1
Received: 21 February 2010; in revised form: 22 April 2010 / Accepted: 26 April 2010 / Published: 28 April 2010
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Abstract: Two isomeric N-(methoxycarbonylthienylmethyl)thioureas were synthesised by a sequence of radical bromination of methylthiophenecarboxylic esters, substitution with trifluoroacetamide anion, deprotection, formation of the corresponding isothiocyanates and addition of ammonia. The interaction of these new thiophene-based thioureas with inducible and neuronal nitric oxide synthase was evaluauted. These novel thienylmethylthioureas stimulated the activity of inducible Nitric Oxide Synthase (iNOS).
Keywords: nitric oxide synthase; iNOS; stimulation; thienylmethylthioureas nitric oxide synthase; iNOS; stimulation; thienylmethylthioureas
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Suaifan, G.A.; Goodyer, C.L.; Threadgill, M.D. Synthesis of N-(Methoxycarbonylthienylmethyl)thioureas and Evaluation of Their Interaction with Inducible and Neuronal Nitric Oxide Synthase. Molecules 2010, 15, 3121-3134.

AMA Style

Suaifan GA, Goodyer CL, Threadgill MD. Synthesis of N-(Methoxycarbonylthienylmethyl)thioureas and Evaluation of Their Interaction with Inducible and Neuronal Nitric Oxide Synthase. Molecules. 2010; 15(5):3121-3134.

Chicago/Turabian Style

Suaifan, Ghadeer A.R.Y.; Goodyer, Claire L.M.; Threadgill, Michael D. 2010. "Synthesis of N-(Methoxycarbonylthienylmethyl)thioureas and Evaluation of Their Interaction with Inducible and Neuronal Nitric Oxide Synthase." Molecules 15, no. 5: 3121-3134.


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