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Molecules 2010, 15(5), 2980-2993; doi:10.3390/molecules15052980
Article

UV-B Induced Changes in the Secondary Metabolites of Morus alba L. Leaves

1,2
, 1,2
, 1
, 1
, 1
, 1
, 3,*  and 1,*
1 The Key Laboratory of Biomedical Engineering Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, Zhejiang, China 2 College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China 3 Department of Biological Sciences, University of Wisconsin—Milwaukee, Milwaukee, WI 53211, USA
* Authors to whom correspondence should be addressed.
Received: 28 January 2010 / Revised: 4 April 2010 / Accepted: 8 April 2010 / Published: 27 April 2010
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Abstract

Ultraviolet-B (UV-B) radiation is harmful to plants and human beings. Many secondary metabolites, like flavonoids, alkaloids, and lignin, are UV-B absorbing compounds, which can protect the genetic material of plants. Furthermore, they are active components of herbal drugs. UV-B radiation can activate the self-protective secondary metabolism system. The results of this paper provide a method to induce bioactive secondary metabolites from mulberry leaves (Morus alba L.) by UV-B irradiation in vitro. Five significantly different chromatographic peaks were found by HPLC fingerprint after induction, from which two active compounds were identified: One was chalcomoracin, a natural Diels-Alder type adduct with antibacterial activity; the other one was moracin N, which is a precursor of chalcomoracin. Their contents were 0.818 mg/g and 0.352 mg/g by dry weight, respectively.
Keywords: UV radiation; chalcomoracin; moracin N; Diels-Alder type adducts; mulberry leaves UV radiation; chalcomoracin; moracin N; Diels-Alder type adducts; mulberry leaves
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Gu, X.-D.; Sun, M.-Y.; Zhang, L.; Fu, H.-W.; Cui, L.; Chen, R.-Z.; Zhang, D.-W.; Tian, J.-K. UV-B Induced Changes in the Secondary Metabolites of Morus alba L. Leaves. Molecules 2010, 15, 2980-2993.

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