Next Article in Journal
UV-B Induced Changes in the Secondary Metabolites of Morus alba L. Leaves
Previous Article in Journal
8-Hydroxyquinoline Dansylates Modified with PAMAM Dendrimer as Fluorescent Fe3+ Sensors
Molecules 2010, 15(5), 2972-2979; doi:10.3390/molecules15052972

A Mild and Facile One-Pot Synthesis of N-Methyl-3-Acyl-Pyrroles

*  and
Department of Chemistry, Faculty of Sciences, Azarbaijan University of Tarbiat Moallem, Tabriz, Iran
* Author to whom correspondence should be addressed.
Received: 28 February 2010 / Revised: 23 March 2010 / Accepted: 18 April 2010 / Published: 27 April 2010
Download PDF [108 KB, 18 June 2014; original version 18 June 2014]


N-Methyl-3-acylpyrroles were synthesized via a multicomponent reaction of dimethylacetylene dicarboxylate (DMAD), N-methylhydroxylamine and acylchlorides in the presence of KHCO3. For comparison both conventional and microwave protocols were examined in this procedure. The reaction is clean and gives the products in good to excellent yields under conventional heating conditions at 40 ºC in anhydrous dichloromethane.
Keywords: 3-acylpyrrole; multicomponent reaction; dimethylacetylene dicarboxylate 3-acylpyrrole; multicomponent reaction; dimethylacetylene dicarboxylate
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Valizadeh, H.; Fakhari, A. A Mild and Facile One-Pot Synthesis of N-Methyl-3-Acyl-Pyrroles. Molecules 2010, 15, 2972-2979.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert