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Molecules 2010, 15(5), 2972-2979; doi:10.3390/molecules15052972

A Mild and Facile One-Pot Synthesis of N-Methyl-3-Acyl-Pyrroles

*  and
Department of Chemistry, Faculty of Sciences, Azarbaijan University of Tarbiat Moallem, Tabriz, Iran
* Author to whom correspondence should be addressed.
Received: 28 February 2010 / Revised: 23 March 2010 / Accepted: 18 April 2010 / Published: 27 April 2010
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N-Methyl-3-acylpyrroles were synthesized via a multicomponent reaction of dimethylacetylene dicarboxylate (DMAD), N-methylhydroxylamine and acylchlorides in the presence of KHCO3. For comparison both conventional and microwave protocols were examined in this procedure. The reaction is clean and gives the products in good to excellent yields under conventional heating conditions at 40 ºC in anhydrous dichloromethane.
Keywords: 3-acylpyrrole; multicomponent reaction; dimethylacetylene dicarboxylate 3-acylpyrrole; multicomponent reaction; dimethylacetylene dicarboxylate
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Valizadeh, H.; Fakhari, A. A Mild and Facile One-Pot Synthesis of N-Methyl-3-Acyl-Pyrroles. Molecules 2010, 15, 2972-2979.

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