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Molecules 2010, 15(5), 2972-2979; doi:10.3390/molecules15052972
Article

A Mild and Facile One-Pot Synthesis of N-Methyl-3-Acyl-Pyrroles

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Received: 28 February 2010; in revised form: 23 March 2010 / Accepted: 18 April 2010 / Published: 27 April 2010
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Abstract: N-Methyl-3-acylpyrroles were synthesized via a multicomponent reaction of dimethylacetylene dicarboxylate (DMAD), N-methylhydroxylamine and acylchlorides in the presence of KHCO3. For comparison both conventional and microwave protocols were examined in this procedure. The reaction is clean and gives the products in good to excellent yields under conventional heating conditions at 40 ºC in anhydrous dichloromethane.
Keywords: 3-acylpyrrole; multicomponent reaction; dimethylacetylene dicarboxylate 3-acylpyrrole; multicomponent reaction; dimethylacetylene dicarboxylate
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MDPI and ACS Style

Valizadeh, H.; Fakhari, A. A Mild and Facile One-Pot Synthesis of N-Methyl-3-Acyl-Pyrroles. Molecules 2010, 15, 2972-2979.

AMA Style

Valizadeh H, Fakhari A. A Mild and Facile One-Pot Synthesis of N-Methyl-3-Acyl-Pyrroles. Molecules. 2010; 15(5):2972-2979.

Chicago/Turabian Style

Valizadeh, Hassan; Fakhari, Ashraf. 2010. "A Mild and Facile One-Pot Synthesis of N-Methyl-3-Acyl-Pyrroles." Molecules 15, no. 5: 2972-2979.


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