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A Mild and Facile One-Pot Synthesis of N-Methyl-3-Acyl-Pyrroles
Department of Chemistry, Faculty of Sciences, Azarbaijan University of Tarbiat Moallem, Tabriz, Iran
* Author to whom correspondence should be addressed.
Received: 28 February 2010; in revised form: 23 March 2010 / Accepted: 18 April 2010 / Published: 27 April 2010
Abstract: N-Methyl-3-acylpyrroles were synthesized via a multicomponent reaction of dimethylacetylene dicarboxylate (DMAD), N-methylhydroxylamine and acylchlorides in the presence of KHCO3. For comparison both conventional and microwave protocols were examined in this procedure. The reaction is clean and gives the products in good to excellent yields under conventional heating conditions at 40 ºC in anhydrous dichloromethane.
Keywords: 3-acylpyrrole; multicomponent reaction; dimethylacetylene dicarboxylate
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Valizadeh, H.; Fakhari, A. A Mild and Facile One-Pot Synthesis of N-Methyl-3-Acyl-Pyrroles. Molecules 2010, 15, 2972-2979.
Valizadeh H, Fakhari A. A Mild and Facile One-Pot Synthesis of N-Methyl-3-Acyl-Pyrroles. Molecules. 2010; 15(5):2972-2979.
Valizadeh, Hassan; Fakhari, Ashraf. 2010. "A Mild and Facile One-Pot Synthesis of N-Methyl-3-Acyl-Pyrroles." Molecules 15, no. 5: 2972-2979.